{"id":"W4413139885","doi":"10.1093/brain/awaf259","title":"Associations between epilepsy-related polygenic risk and brain morphology in childhood","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Queen's University; Université de Sherbrooke; McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"Epilepsy Canada; National Institute of Neurological Disorders and Stroke; National Medical Research Council; National Center for Advancing Translational Sciences; Montreal Neurological Institute and Hospital; Epilepsy Society; Medical Research Council; National Institutes of Health; Canadian Institutes of Health Research; Temasek Foundation; Health and Care Research Wales; Fonds de Recherche du Québec - Santé; Centro Singular de Investigación de Galicia; Sick Kids Foundation; Medical Research Centre; Saastamoisen säätiö; National Science Foundation; China Postdoctoral Science Foundation; Consejo Nacional de Ciencia y Tecnología, Paraguay; Norges Idrettshøgskole; Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn; Xuzhou Medical University; Centre Azrieli de recherche sur l'autisme, Institut et Hôpital Neurologiques de Montréal; University College London Hospitals NHS Foundation Trust; Canadian Open Neuroscience Platform; National Center for Geriatrics and Gerontology; Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México; Consejo Nacional de Ciencia y Tecnología; Canada Research Chairs; Conselho Nacional de Desenvolvimento Científico e Tecnológico; National Natural Science Foundation of China; Michael J. Fox Foundation for Parkinson's Research; National Health and Medical Research Council; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; Deutsche Forschungsgemeinschaft; Fondation Brain Canada; Ministry of Health -Singapore; National University of Singapore; Université de Sherbrooke; University College London; Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Consortium canadien en neurodégénérescence associée au vieillissement; Ministero della Salute; Australian Government; Galen and Hilary Weston Foundation","keywords":"Neurotypical; Epilepsy; Temporal lobe; Neuroimaging; Atrophy; Hippocampal sclerosis; Brain morphometry; Neuroscience; Population; Genetic architecture; Psychology; Epilepsy syndromes; Magnetic resonance imaging; Medicine; Pathology; Autism; Quantitative trait locus; Developmental psychology; Autism spectrum disorder","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003399751,0.0003755915,0.0002071551,0.0008775393,0.0002457537,0.0003442053,0.0001936804,0.0002637299,0.001357495],"category_scores_gemma":[0.001232705,0.000183704,0.0002916997,0.0008562257,0.0004508525,0.0002473838,0.0006138012,0.0002332152,0.0001041699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002554398,"about_ca_system_score_gemma":0.0001936034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006708958,"about_ca_topic_score_gemma":0.0120052,"domain_scores_codex":[0.9996346,0.00008945339,0.00003387467,0.0001438787,0.00004628038,0.00005200725],"domain_scores_gemma":[0.9991363,0.0002005467,0.0004389885,0.0001214581,0.00004105588,0.00006163629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008088083,0.00001134727,0.9956306,0.000009421366,0.00009043161,0.0002218917,0.0001048079,0.0003876342,0.001204624,0.0001057004,0.00003582551,0.002116842],"study_design_scores_gemma":[0.000001203981,0.00001630709,0.9993873,0.000001772893,0.00001100742,0.0002018894,0.0000298951,0.0001673347,0.0001002846,0.00004981821,0.00003193691,0.000001305957],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994714,0.00007576967,0.0001438882,0.00001207996,4.844788e-7,0.00000200854,0.0001525243,0.000004621551,0.0001372425],"genre_scores_gemma":[0.9995105,0.00007292635,0.0001558385,0.000003013215,0.000001105525,0.000002674112,0.0002029007,0.000002275101,0.00004873166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006708958,"threshold_uncertainty_score":0.01333982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01559721570254171,"score_gpt":0.2646586077394115,"score_spread":0.2490613920368697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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