{"id":"W4413139885","doi":"10.1093/brain/awaf259","title":"Associations between epilepsy-related polygenic risk and brain morphology in childhood","year":2025,"lang":"en","type":"article","venue":"Brain","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Queen's University; Université de Sherbrooke; McGill University; McGill Genome Centre; Montreal Neurological Institute and Hospital","funders":"Epilepsy Canada; National Institute of Neurological Disorders and Stroke; National Medical Research Council; National Center for Advancing Translational Sciences; Montreal Neurological Institute and Hospital; Epilepsy Society; Medical Research Council; National Institutes of Health; Canadian Institutes of Health Research; Temasek Foundation; Health and Care Research Wales; Fonds de Recherche du Québec - Santé; Centro Singular de Investigación de Galicia; Sick Kids Foundation; Medical Research Centre; Saastamoisen säätiö; National Science Foundation; China Postdoctoral Science Foundation; Consejo Nacional de Ciencia y Tecnología, Paraguay; Norges Idrettshøgskole; Medizinische Fakultät, Rheinische Friedrich-Wilhelms-Universität Bonn; Xuzhou Medical University; Centre Azrieli de recherche sur l'autisme, Institut et Hôpital Neurologiques de Montréal; University College London Hospitals NHS Foundation Trust; Canadian Open Neuroscience Platform; National Center for Geriatrics and Gerontology; Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México; Consejo Nacional de Ciencia y Tecnología; Canada Research Chairs; Conselho Nacional de Desenvolvimento Científico e Tecnológico; National Natural Science Foundation of China; Michael J. Fox Foundation for Parkinson's Research; National Health and Medical Research Council; European Commission; Fundação de Amparo à Pesquisa do Estado de São Paulo; Deutsche Forschungsgemeinschaft; Fondation Brain Canada; Ministry of Health -Singapore; National University of Singapore; Université de Sherbrooke; University College London; Natural Sciences and Engineering Research Council of Canada; Bundesministerium für Bildung und Forschung; National Institute for Health and Care Research; Consortium canadien en neurodégénérescence associée au vieillissement; Ministero della Salute; Australian Government; Galen and Hilary Weston Foundation","keywords":"Neurotypical; Epilepsy; Temporal lobe; Neuroimaging; Atrophy; Hippocampal sclerosis; Brain morphometry; Neuroscience; Population; Genetic architecture; Psychology; Epilepsy syndromes; Magnetic resonance imaging; Medicine; Pathology; Autism; Quantitative trait locus; Developmental psychology; Autism spectrum disorder","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.0006743516,0.0001544142,0.0002942602,0.0003536255,0.0004505599,0.00003384519,0.0001998991,0.0001379302,0.00003400492],"category_scores_gemma":[0.04081957,0.0001648821,0.00006260453,0.0009768121,0.0001611424,0.0001535926,0.0003619444,0.0003901168,0.00003902971],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001060468,"about_ca_system_score_gemma":0.00008503154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002613575,"about_ca_topic_score_gemma":0.0003133969,"domain_scores_codex":[0.9980837,0.0005733358,0.0003096527,0.0005700715,0.0001469386,0.0003163038],"domain_scores_gemma":[0.9828457,0.01675682,0.0001173002,0.0002154388,0.00001951223,0.00004520299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00001589175,0.0001701337,0.9192811,0.000006569976,0.00007356516,0.00001718331,0.0009411461,0.00006118425,0.00807074,0.0130814,0.04780406,0.01047704],"study_design_scores_gemma":[0.0009301392,0.00004686295,0.967375,0.00001508851,0.0000158474,0.000004321118,0.0000263921,0.00005349693,0.00182977,0.02627166,0.003290586,0.0001408752],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.91632,0.0001268284,0.0001436466,0.07930156,0.0002476142,0.0003159806,0.0002155896,0.0001089421,0.00321988],"genre_scores_gemma":[0.987366,0.00002289739,0.0000441062,0.01076599,0.00004439878,0.00002836773,0.00001117393,0.00001346415,0.001703605],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07104605,"threshold_uncertainty_score":0.96726,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01559721570254171,"score_gpt":0.2646586077394115,"score_spread":0.2490613920368697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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