{"id":"W4413140809","doi":"10.1503/jpn.250076","title":"Weight loss leading to reduction in clozapine levels and symptomatic worsening","year":2025,"lang":"en","type":"article","venue":"Journal of Psychiatry and Neuroscience","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Banting and Best Diabetes Centre, University of Toronto; Faculty of Health and Medical Sciences, University of Western Australia; University of Toronto","keywords":"Clozapine; Weight loss; Reduction (mathematics); Medicine; Internal medicine; Schizophrenia (object-oriented programming); Psychiatry; Mathematics; Obesity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001587931,0.0003153948,0.0004221305,0.0002995786,0.0003942519,0.0002579147,0.0002808443,0.0008084221,0.002707824],"category_scores_gemma":[0.0008843834,0.0001411585,0.0006745906,0.000211989,0.0001953546,0.0002076111,0.0002424766,0.001360477,0.0003292509],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007197308,"about_ca_system_score_gemma":0.0007484383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006532812,"about_ca_topic_score_gemma":0.01487221,"domain_scores_codex":[0.9998783,0.0000180965,0.00001824893,0.00001443839,0.00002863065,0.0000422817],"domain_scores_gemma":[0.9997402,0.00004793682,0.00004031025,0.00001978173,0.00003542309,0.000116378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.1529187,0.009747176,0.1356267,0.001160446,0.001376511,0.1489802,0.0008587477,0.002460506,0.1176579,0.002047761,0.009137266,0.4180282],"study_design_scores_gemma":[0.005709123,0.03109665,0.8754703,0.000194064,0.0008229275,0.04937145,0.000580759,0.005175965,0.01904147,0.001631569,0.01079146,0.0001143028],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759908,0.001766207,0.001007705,0.002846363,0.0002977755,0.0004741637,0.0005592098,0.0001638417,0.01689385],"genre_scores_gemma":[0.9960692,0.0004694087,0.0004393471,0.0005079823,0.00005690166,0.0000264069,0.0002761731,0.000005629048,0.002148912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006532812,"threshold_uncertainty_score":0.01298958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02443773217156427,"score_gpt":0.3350354861683876,"score_spread":0.3105977539968234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}