{"id":"W4413140931","doi":"10.1016/j.vaccine.2025.127393","title":"The impact of egg adaptation and immune imprinting on influenza vaccine effectiveness","year":2025,"lang":"en","type":"article","venue":"Vaccine","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Seqirus","keywords":"Biology; Immune system; Imprinting (psychology); Vaccination; Antigen; Immunology; Virology; Influenza vaccine; Original antigenic sin; Antibody; Virus; Antigenic drift; Influenza A virus; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008032332,0.0003074841,0.0005773203,0.0006305291,0.0001247154,0.0006905306,0.000397071,0.0005746561,0.001546141],"category_scores_gemma":[0.001996726,0.000168281,0.000552158,0.0005382039,0.0003805751,0.0007069218,0.0004099018,0.0006427703,0.0003624259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004982352,"about_ca_system_score_gemma":0.0005929004,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001413097,"about_ca_topic_score_gemma":0.001361379,"domain_scores_codex":[0.9996222,0.0001060282,0.00005409657,0.00008630842,0.00008884338,0.00004247421],"domain_scores_gemma":[0.9990795,0.0006733275,0.0001223649,0.00001481397,0.00008752945,0.00002257737],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0002811489,0.00005258646,0.008682312,0.03129205,0.0005899914,0.0007290383,0.0004744909,0.002131216,0.01361968,0.006800838,0.007780516,0.9275662],"study_design_scores_gemma":[0.00003278016,0.0008648394,0.0842781,0.01029276,0.001090982,0.004941073,0.0004704055,0.0009080819,0.0150701,0.005153444,0.8767819,0.0001155214],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.005942324,0.9904612,0.0004421122,0.0003894418,0.0001451307,0.000007205017,0.0001039586,0.00001089899,0.002497672],"genre_scores_gemma":[0.0281742,0.9700291,0.0004336887,0.0002720339,0.0001778674,0.00001599105,0.0001096667,0.000005977882,0.0007815373],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001546141,"threshold_uncertainty_score":0.005172372,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04354084195462084,"score_gpt":0.3983943900905064,"score_spread":0.3548535481358856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}