{"id":"W4413141259","doi":"10.1080/21505594.2025.2546067","title":"Intrinsic and extrinsic factors affecting the evolution of virulence in the HIV-associated opportunistic human fungal pathogen <i>Cryptococcus neoformans</i>","year":2025,"lang":"en","type":"article","venue":"Virulence","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Natural Science Foundation of China","keywords":"Virulence; Biology; Pathogen; Opportunistic pathogen; Human pathogen; Fungal pathogen; Microbiology; Virology; Virulence factor; Human immunodeficiency virus (HIV); Immunology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001216016,0.0001844689,0.0003196086,0.00011941,0.0003039945,0.00002512231,0.0002575813,0.0001076222,0.00001711006],"category_scores_gemma":[0.0007811186,0.0001103184,0.00008794403,0.0006689616,0.0003488208,0.0001274983,0.00009383799,0.0004163439,0.000005142247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002072908,"about_ca_system_score_gemma":0.0002032836,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003390103,"about_ca_topic_score_gemma":0.0004483541,"domain_scores_codex":[0.9983535,0.0002409861,0.0004300513,0.0003151526,0.0003349814,0.0003252657],"domain_scores_gemma":[0.9986861,0.0005141956,0.0001735954,0.0004684667,0.0001063796,0.0000513015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00008982828,0.0001655383,0.9311859,0.0001700627,0.0000252061,0.0000231167,0.001405796,0.000001626687,0.05952455,0.003376511,0.0001481138,0.003883743],"study_design_scores_gemma":[0.0005561591,0.0001512161,0.9921265,0.0004719759,0.00008709761,0.000004255203,0.004811771,0.00009255719,0.0008132515,0.0006420454,0.0001366838,0.0001064473],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962375,0.0006106956,0.0002996807,0.0002404992,0.00008134737,0.0007476945,0.00004801617,0.00003263363,0.001701999],"genre_scores_gemma":[0.9994147,0.0001091936,0.0000127114,0.0002173414,0.00002406456,0.00002001288,0.00001801504,0.000008113792,0.0001758542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06094064,"threshold_uncertainty_score":0.4498652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01802793043989926,"score_gpt":0.2830894534991048,"score_spread":0.2650615230592056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}