{"id":"W4413141708","doi":"10.20944/preprints202508.0388.v1","title":"Non-Competitive AMPA Receptor Antagonist Perampanel Inhibits Ischemia-Induced Neurodegeneration and Behavioral Deficits in Focal Cortical Pial Vessel Disruption Stroke Model","year":2025,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Natural Sciences and Engineering Research Council of Canada; Saskatchewan Health Research Foundation; Heart and Stroke Foundation of Canada","keywords":"Perampanel; Neuroprotection; AMPA receptor; Neurodegeneration; Glutamate receptor; Brain ischemia; Neuroscience; NMDA receptor; Pharmacology; Epilepsy; Medicine; Ischemia; Anesthesia; Psychology; Receptor; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001095206,0.0005035599,0.0007723325,0.0003350363,0.0001473604,0.0001893988,0.000445664,0.0003130361,0.001300854],"category_scores_gemma":[0.00009758783,0.0002030092,0.000321171,0.0002516322,0.0001998406,0.0003183438,0.0001506974,0.0009365026,0.0003904769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002294319,"about_ca_system_score_gemma":0.0002642124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005014005,"about_ca_topic_score_gemma":0.001163638,"domain_scores_codex":[0.9998883,0.0000122647,0.00001530824,0.00001486098,0.00002681327,0.00004253137],"domain_scores_gemma":[0.9999419,0.000004188954,0.00002240272,0.00000630744,0.000007792394,0.00001744882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007517218,0.0002852228,0.0001261932,0.0002231513,0.00003444411,0.0001080479,0.00002167376,0.0001357464,0.9949471,0.00009994279,0.0002211018,0.003045615],"study_design_scores_gemma":[0.0002415057,0.003530671,0.003182975,0.00002244965,0.00007241627,0.0004754035,0.00003959465,0.001452158,0.9889715,0.00009450745,0.001905926,0.00001092205],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913841,0.004037358,0.001868153,0.0002114579,0.00006939573,0.00005879977,0.0004391317,0.0001825489,0.001748935],"genre_scores_gemma":[0.9891419,0.005129934,0.001981624,0.00008363651,0.00002477738,0.0001653103,0.0007452729,0.00001629043,0.002711202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001300854,"threshold_uncertainty_score":0.004351735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1876541959664371,"score_gpt":0.417014486643601,"score_spread":0.2293602906771639,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}