{"id":"W4413148372","doi":"10.18295/2075-0528.1377","title":"Immunotherapy for B-Cell Neoplasms using T Cells expressing Chimeric Antigen Receptors : From antigen choice to clinical implementation","year":2012,"lang":"en","type":"article","venue":"Sultan Qaboos University medical journal","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; University of Saskatchewan; McGill University Health Centre","funders":"","keywords":"Chimeric antigen receptor; Medicine; Immunotherapy; Antigen; Receptor; Immunology; Antigen-presenting cell; T cell; Immune system; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001766359,0.0002483148,0.0005390809,0.0003894716,0.0005071152,0.00006738032,0.0004266347,0.0002772547,0.01070352],"category_scores_gemma":[0.0002366887,0.0002382784,0.0003523365,0.0005652764,0.0001733753,0.000395471,0.0001205885,0.0008766169,0.0000558177],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004315979,"about_ca_system_score_gemma":0.0008129861,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003821767,"about_ca_topic_score_gemma":0.00002458116,"domain_scores_codex":[0.9965752,0.0004237005,0.0006024918,0.0003552106,0.001170303,0.0008730658],"domain_scores_gemma":[0.9967272,0.0007189229,0.0002788844,0.0002913852,0.0003051008,0.001678495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003368883,0.0008619283,0.2067938,0.00003123611,0.0005707863,0.0001187784,0.003978169,0.000007048342,0.5719758,0.000004447102,0.009192333,0.2030968],"study_design_scores_gemma":[0.02203397,0.001297135,0.0610025,0.0003659498,0.0002550461,0.0001465602,0.008658525,0.00065956,0.09999458,0.00001642987,0.8048983,0.0006714853],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805894,0.0004155615,0.0153711,0.000769849,0.001687744,0.0007060521,0.00004352765,0.00004241463,0.0003743394],"genre_scores_gemma":[0.9455018,0.004547962,0.03720335,0.001905051,0.007843932,0.000002167586,0.0001328776,0.0001438066,0.002719056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7957059,"threshold_uncertainty_score":0.9902008,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06018600695271235,"score_gpt":0.3941796720039296,"score_spread":0.3339936650512172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}