{"id":"W4413149761","doi":"10.1055/a-2661-3593","title":"Stereocontrolled Synthesis of 2S,3R-(3)-Piperidinyl Glycine and 2S,4S-(3)-Piperidinyl Alanine: Medicinally Relevant Constrained Cyclic Amino Acids","year":2025,"lang":"en","type":"article","venue":"Synthesis","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Glycine; Alanine; Stereochemistry; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701435,0.0003737744,0.00020397,0.0001405105,0.0001064711,0.0001490387,0.0002483878,0.0002442657,0.001679589],"category_scores_gemma":[0.0001291746,0.0001210151,0.0001391212,0.0001562283,0.000116448,0.0001875741,0.0002051864,0.0002718401,0.0006801396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000199696,"about_ca_system_score_gemma":0.0003603096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002535709,"about_ca_topic_score_gemma":0.0005506245,"domain_scores_codex":[0.9999114,0.00001814042,0.000008533413,0.00001906029,0.00001833639,0.0000243854],"domain_scores_gemma":[0.9999284,0.000006009515,0.00002781776,0.000007287384,0.00001261392,0.00001787623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008880902,0.00002162119,0.00005348614,0.0001013149,0.000005013905,0.0001515555,0.00003882744,0.000371363,0.9935694,0.0005345647,0.00008372095,0.004980379],"study_design_scores_gemma":[0.00003844659,0.0006006908,0.0006744586,0.00001049887,0.0000120799,0.0003938361,0.00002397676,0.0008352059,0.9887251,0.0001367868,0.008531238,0.00001767504],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9591107,0.0024121,0.024074,0.0001625906,0.00009155965,0.0002416309,0.001129962,0.0002429696,0.01253442],"genre_scores_gemma":[0.9738799,0.001518807,0.02060203,0.00007039455,0.00001899916,0.00008950094,0.0004553873,0.00004014856,0.003324883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001679589,"threshold_uncertainty_score":0.005618811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004142015871563974,"score_gpt":0.2274032844482815,"score_spread":0.2232612685767175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}