{"id":"W4413149761","doi":"10.1055/a-2661-3593","title":"Stereocontrolled Synthesis of 2S,3R-(3)-Piperidinyl Glycine and 2S,4S-(3)-Piperidinyl Alanine: Medicinally Relevant Constrained Cyclic Amino Acids","year":2025,"lang":"en","type":"article","venue":"Synthesis","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Glycine; Alanine; Stereochemistry; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006356438,0.000521626,0.001217814,0.000253903,0.0001725861,0.00004976906,0.0004741877,0.0003922358,0.000294041],"category_scores_gemma":[0.003168166,0.0004326488,0.0004866721,0.0003974306,0.0005302793,0.00001200668,0.0002463727,0.000167494,0.000008900888],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004010283,"about_ca_system_score_gemma":0.000126398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001380639,"about_ca_topic_score_gemma":0.00005254612,"domain_scores_codex":[0.9970859,0.00021261,0.0009041865,0.0008920034,0.0003527561,0.0005525692],"domain_scores_gemma":[0.9977582,0.0006792959,0.0003238758,0.0008343685,0.0001781864,0.0002261508],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004947165,0.0001738923,0.004315881,0.0001837719,0.0008846932,0.00001203747,0.000033311,0.000004014144,0.9483487,0.0001800217,0.000808725,0.04456021],"study_design_scores_gemma":[0.001055294,0.0001316358,0.004701613,0.0003823764,0.0009444762,0.00002171427,0.0003454507,0.0002552736,0.9832493,0.000115414,0.008315941,0.0004814851],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9848793,0.002649591,0.0006013804,0.002783917,0.0001107086,0.0003761709,0.0001413013,0.0000479819,0.008409641],"genre_scores_gemma":[0.9957768,0.001534075,0.0008854888,0.0002927945,0.0001826275,0.0001640914,0.00002824741,0.00004693025,0.001088913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04407873,"threshold_uncertainty_score":0.9998125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004142015871563974,"score_gpt":0.2274032844482815,"score_spread":0.2232612685767175,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}