{"id":"W4413158372","doi":"10.2139/ssrn.5386791","title":"Nilotinib Versus Nilotinib Combined to Pegylated Interferon-Alpha2a as First-Line Therapy in Chronic Phase Chronic Myeloid Leukaemia. Final Results of the National Academic Phase Iii Petals Trial","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hotel Dieu Hospital","funders":"","keywords":"Nilotinib; Chronic myeloid leukaemia; Medicine; Petal; Internal medicine; Phase (matter); First line therapy; Pegylated interferon; Oncology; Virology; Tyrosine kinase; Biology; Physics; Receptor; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001154794,0.001006229,0.001861214,0.0002478061,0.0002345695,0.001224195,0.0005358505,0.0008230002,0.006711387],"category_scores_gemma":[0.001482108,0.0002492903,0.001481296,0.0003134314,0.0005386252,0.0008603378,0.000409725,0.002206415,0.001428464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001005575,"about_ca_system_score_gemma":0.0009648974,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008759667,"about_ca_topic_score_gemma":0.002637376,"domain_scores_codex":[0.9994869,0.0003414467,0.00002187655,0.00004756147,0.00003401964,0.00006807189],"domain_scores_gemma":[0.9995067,0.0001367334,0.0001099736,0.00003272195,0.00003585597,0.0001780132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9009513,0.00212745,0.0009565949,0.00103548,0.002032803,0.0000839196,0.00005333293,0.001240787,0.002688777,0.0004294622,0.00833973,0.08006035],"study_design_scores_gemma":[0.9047347,0.07155831,0.007435064,0.0002620434,0.001903862,0.0002631483,0.00009904303,0.001762954,0.001140457,0.001206565,0.009596066,0.00003783296],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9453426,0.02806991,0.0008910477,0.004048043,0.001493179,0.0009456399,0.004178978,0.0002689783,0.01476176],"genre_scores_gemma":[0.9736561,0.006728828,0.001220163,0.002197603,0.0006579505,0.0009932446,0.003904276,0.00005743293,0.01058431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006711387,"threshold_uncertainty_score":0.02245188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06326698993351434,"score_gpt":0.3881469448736939,"score_spread":0.3248799549401796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}