{"id":"W4413160413","doi":"10.1016/j.drudis.2025.104453","title":"Commercialization of cell and gene therapy in Canada: Current landscape, challenges and opportunities","year":2025,"lang":"en","type":"review","venue":"Drug Discovery Today","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Commercialization; Current (fluid); Genetic enhancement; Gene; Biotechnology; Computational biology; Business; Biology; Engineering; Genetics; Marketing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002842445,0.000705203,0.001155372,0.004275416,0.001661013,0.00480077,0.001351931,0.001981382,0.006786926],"category_scores_gemma":[0.003989788,0.0003247608,0.0007764588,0.01035864,0.001789814,0.002137206,0.001160596,0.002205562,0.0009347447],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02453332,"about_ca_system_score_gemma":0.103383,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.6000534,"about_ca_topic_score_gemma":0.7245417,"domain_scores_codex":[0.9983028,0.0001675015,0.0001127573,0.0001350438,0.0009736767,0.0003082425],"domain_scores_gemma":[0.995177,0.001388844,0.0003265195,0.00005749061,0.002671583,0.0003785626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008677774,0.0000561359,0.0007226291,0.03232274,0.0001083008,0.00031177,0.0003773327,0.0005835071,0.0009331995,0.04058014,0.08378542,0.8401321],"study_design_scores_gemma":[0.00001440487,0.0000304099,0.001823692,0.01419358,0.0001284254,0.0002643546,0.0004681358,0.0001388679,0.0003485186,0.002479769,0.9800797,0.00003013758],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003257613,0.9899041,0.0000999176,0.004326307,0.0001944458,0.00000963377,0.0001080655,0.000009600258,0.005022102],"genre_scores_gemma":[0.002243313,0.996008,0.0001857461,0.0006829584,0.00004781921,0.000005504311,0.00007172915,0.000003040468,0.0007518194],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9754667,"threshold_uncertainty_score":0.8046039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09829680913850976,"score_gpt":0.3382983723454111,"score_spread":0.2400015632069014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}