{"id":"W4413160413","doi":"10.1016/j.drudis.2025.104453","title":"Commercialization of cell and gene therapy in Canada: Current landscape, challenges and opportunities","year":2025,"lang":"en","type":"review","venue":"Drug Discovery Today","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Commercialization; Current (fluid); Genetic enhancement; Gene; Biotechnology; Computational biology; Business; Biology; Engineering; Genetics; Marketing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002983736,0.0002796766,0.001345035,0.0003119106,0.00002492467,0.00002055255,0.000105163,0.00008983715,0.00008293568],"category_scores_gemma":[0.00001831836,0.0002183258,0.00009100928,0.0001351776,0.00006703274,0.00007517197,0.00009874176,0.0002871199,2.185722e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001780262,"about_ca_system_score_gemma":0.003153868,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.04387325,"about_ca_topic_score_gemma":0.1417039,"domain_scores_codex":[0.9984884,0.0002365247,0.000443112,0.0003098648,0.0003053732,0.0002167499],"domain_scores_gemma":[0.9991015,0.0003098908,0.0001524343,0.0002955405,0.00005200744,0.00008869551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000402968,0.00007685323,0.0001440511,0.02323642,0.00006214654,0.00001856106,0.0002915041,1.849769e-7,0.000004460095,0.000119607,0.0007336973,0.9752722],"study_design_scores_gemma":[0.0008692659,0.00006092784,0.0003426703,0.01058916,0.0001461093,0.000009444366,0.0003954394,0.000005770793,0.00005327046,0.00002135322,0.9872907,0.0002158789],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001622739,0.9939579,0.000001427458,0.0002241491,0.0001656567,0.0008377323,0.0001601766,0.000005779,0.003024424],"genre_scores_gemma":[0.0005513937,0.996173,0.000003164738,0.00005157376,0.00007460175,0.00006452644,0.0003205504,0.000030186,0.002730973],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.986557,"threshold_uncertainty_score":0.9624937,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09829680913850976,"score_gpt":0.3382983723454111,"score_spread":0.2400015632069014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}