{"id":"W4413163974","doi":"10.1016/j.neurot.2025.e00648","title":"Azetukalner, a Novel, Potent KV7 Potassium Channel Opener in Development for the Treatment of Focal Onset Seizures, Primary Generalized Tonic-Clonic Seizures, and Major Depressive Disorder","year":2025,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Potassium channel opener; Neurology; Tonic (physiology); Medicine; Epilepsy; Potassium channel; Neuroscience; Anesthesia; Psychology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000215248,0.0003204907,0.0003507496,0.0002568502,0.0001647576,0.0003160606,0.0003319023,0.0002677949,0.002343595],"category_scores_gemma":[0.0001404269,0.0001273518,0.0002481518,0.000175522,0.0001850803,0.0002609198,0.0001577857,0.000628642,0.0004281256],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000288288,"about_ca_system_score_gemma":0.0002507656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007814059,"about_ca_topic_score_gemma":0.004232952,"domain_scores_codex":[0.9999415,0.00001439129,0.000003745946,0.000012983,0.00001309086,0.00001431475],"domain_scores_gemma":[0.9999658,0.000004959939,0.00001068032,0.000002181679,0.000004978735,0.00001128711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008803507,0.002526239,0.002664345,0.001365126,0.0004735559,0.0007340669,0.0001940461,0.002296787,0.6040381,0.003461343,0.008136557,0.3653063],"study_design_scores_gemma":[0.0580784,0.1869964,0.06232455,0.000677357,0.001214937,0.01711954,0.0003042307,0.01205259,0.4319389,0.002832378,0.2261474,0.0003133726],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9381065,0.03901101,0.006960447,0.0008811908,0.0002142284,0.0005994397,0.0008898485,0.0005876132,0.01274967],"genre_scores_gemma":[0.9644152,0.02039876,0.005255634,0.0004797841,0.00005017798,0.0001671641,0.001228432,0.000028058,0.007976904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002343595,"threshold_uncertainty_score":0.007840097,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02184523256491894,"score_gpt":0.2680573998232457,"score_spread":0.2462121672583267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}