{"id":"W4413163974","doi":"10.1016/j.neurot.2025.e00648","title":"Azetukalner, a Novel, Potent KV7 Potassium Channel Opener in Development for the Treatment of Focal Onset Seizures, Primary Generalized Tonic-Clonic Seizures, and Major Depressive Disorder","year":2025,"lang":"en","type":"article","venue":"Neurotherapeutics","topic":"Coordination Chemistry and Organometallics","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Xenon Pharmaceuticals (Canada)","funders":"","keywords":"Potassium channel opener; Neurology; Tonic (physiology); Medicine; Epilepsy; Potassium channel; Neuroscience; Anesthesia; Psychology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001000132,0.0003249503,0.0003805344,0.00007449292,0.0002074065,0.00005364935,0.0002913409,0.0001758078,0.00006706788],"category_scores_gemma":[0.00002445701,0.0002470835,0.0001168063,0.0002106757,0.0001073002,0.00004840352,0.00007703394,0.0001502205,6.048646e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001855021,"about_ca_system_score_gemma":0.000316209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004662629,"about_ca_topic_score_gemma":0.0001595443,"domain_scores_codex":[0.998508,0.00002836928,0.0004812745,0.0004437321,0.0001984531,0.0003401569],"domain_scores_gemma":[0.9989704,0.0003016135,0.0001558271,0.0004268889,0.00008451351,0.00006072615],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004570561,0.01177769,0.01320778,0.003031929,0.003898624,0.0001154009,0.006286952,0.005451711,0.568498,0.002926425,0.001325828,0.3789091],"study_design_scores_gemma":[0.01420912,0.0001697934,0.004843745,0.0001173487,0.0004198449,0.00005834449,0.0002766272,0.005801121,0.4782433,0.0003173347,0.4949224,0.0006210168],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9656223,0.01809145,0.006101245,0.006395173,0.0003195357,0.001600721,0.0003670093,0.00009199807,0.001410559],"genre_scores_gemma":[0.9870209,0.002176014,0.001096392,0.001493928,0.00008311358,0.0007207731,0.0001581319,0.00006931488,0.007181459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4935966,"threshold_uncertainty_score":0.9999982,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02184523256491894,"score_gpt":0.2680573998232457,"score_spread":0.2462121672583267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}