{"id":"W4413181324","doi":"10.3389/fendo.2025.1623800","title":"Fasting elicits gut microbiome signature changes that extend to type 1 diabetes patients","year":2025,"lang":"en","type":"article","venue":"Frontiers in Endocrinology","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; CH.I.L.D. Foundation; Crohn's and Colitis Canada","keywords":"Microbiome; Gut flora; Type 1 diabetes; Type 2 diabetes; Lachnospiraceae; Immunology; Medicine; Diabetes mellitus; Gut microbiome; Disease; Population; Autoimmunity; Biology; Bioinformatics; Internal medicine; Endocrinology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001938334,0.0002508441,0.0004359068,0.0002672078,0.0003430801,0.0004247919,0.00007829261,0.0003189052,0.001780567],"category_scores_gemma":[0.0006979862,0.0001490824,0.0003396623,0.0004048858,0.0001372119,0.0001680817,0.0004284483,0.0004844566,0.0001749834],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001735653,"about_ca_system_score_gemma":0.0001770925,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001110339,"about_ca_topic_score_gemma":0.001339712,"domain_scores_codex":[0.9998195,0.0000465358,0.00001628528,0.00005317773,0.0000197079,0.0000449132],"domain_scores_gemma":[0.9996903,0.00005036426,0.0001216317,0.00002645055,0.00002932462,0.00008188699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01255931,0.0004162669,0.8611432,0.0002375793,0.0003079487,0.001807688,0.0009191081,0.0002255886,0.08064073,0.00009699596,0.0009013705,0.04074428],"study_design_scores_gemma":[0.00001839049,0.0004742326,0.9971454,0.00001790846,0.00005165874,0.0005592451,0.0002493304,0.00009543615,0.0007307494,0.00005918367,0.000587941,0.00001048623],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998449,0.0006569666,0.0001257239,0.00005945475,0.00001733493,0.000009503793,0.0002651141,0.000006728088,0.0004101874],"genre_scores_gemma":[0.9988938,0.0002792538,0.000150086,0.0001052915,0.00001691914,0.0000132605,0.0003086666,0.000003475125,0.0002291719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001780567,"threshold_uncertainty_score":0.00595659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007116342306949681,"score_gpt":0.2469565125644565,"score_spread":0.2398401702575068,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}