{"id":"W4413192962","doi":"10.1021/acscentsci.5c00606","title":"Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking","year":2025,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Division of Chemistry; National Institute of General Medical Sciences; National Cancer Institute; National Key Research and Development Program of China; European Regional Development Fund; Institut National de la Santé et de la Recherche Médicale; NYU Grossman School of Medicine; Fondation Leducq; National Center of Competence in Research Chemical Biology; Studienstiftung des Deutschen Volkes; Centre National de la Recherche Scientifique; Chinese Academy of Sciences; Directorate for Biological Sciences; Euskal Herriko Unibertsitatea; Augsburg University; National Institutes of Health; Agencia Estatal de Investigación; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; York University; University of Pennsylvania; École Polytechnique Fédérale de Lausanne; Université de Genève; Eusko Jaurlaritza; Universidad de Sevilla; Universiteit Utrecht; California Institute of Technology; Deutsche Forschungsgemeinschaft; Alexander von Humboldt-Stiftung; National Science Foundation","keywords":"Golgi apparatus; Viscosity; Membrane; Control (management); Cell biology; Chemistry; Endoplasmic reticulum; Biophysics; Biology; Computer science; Physics; Biochemistry; Artificial intelligence; Thermodynamics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001205618,0.0001910369,0.00008883831,0.0001211079,0.000149388,0.0002889608,0.0002731271,0.0002353375,0.001398569],"category_scores_gemma":[0.0002020358,0.0001323927,0.0000854645,0.0000833763,0.0002686695,0.0002801458,0.0002778974,0.0004317819,0.0001758914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004478013,"about_ca_system_score_gemma":0.0002098295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005022404,"about_ca_topic_score_gemma":0.000970067,"domain_scores_codex":[0.9999337,0.000006834367,0.000004174245,0.00001796722,0.00002047203,0.00001678994],"domain_scores_gemma":[0.9998887,0.00004743958,0.00003073065,0.000009190603,0.00001211425,0.00001184177],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001428112,0.000004534859,0.00003833339,0.000006673768,7.301678e-7,0.000007549759,0.000005143203,0.00003840137,0.9992031,0.00009365156,0.00001487133,0.0005726328],"study_design_scores_gemma":[0.000004570268,0.00002669532,0.0006432548,0.000001189518,0.000001531534,0.00001346162,0.000008823447,0.0009555655,0.9979706,0.00003364457,0.000338831,0.000001888876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924723,0.0002459664,0.004911398,0.0001350737,0.00001819839,0.00001566729,0.00008074561,0.00008418134,0.002036357],"genre_scores_gemma":[0.9923325,0.000467316,0.004718649,0.00006050233,0.00001165791,0.00003617251,0.00006439653,0.00003638234,0.002272489],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398569,"threshold_uncertainty_score":0.004678667,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02160857482239701,"score_gpt":0.3126459686158254,"score_spread":0.2910373937934284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}