{"id":"W4413192962","doi":"10.1021/acscentsci.5c00606","title":"Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking","year":2025,"lang":"en","type":"article","venue":"ACS Central Science","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Division of Chemistry; National Institute of General Medical Sciences; National Cancer Institute; National Key Research and Development Program of China; European Regional Development Fund; Institut National de la Santé et de la Recherche Médicale; NYU Grossman School of Medicine; Fondation Leducq; National Center of Competence in Research Chemical Biology; Studienstiftung des Deutschen Volkes; Centre National de la Recherche Scientifique; Chinese Academy of Sciences; Directorate for Biological Sciences; Euskal Herriko Unibertsitatea; Augsburg University; National Institutes of Health; Agencia Estatal de Investigación; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; York University; University of Pennsylvania; École Polytechnique Fédérale de Lausanne; Université de Genève; Eusko Jaurlaritza; Universidad de Sevilla; Universiteit Utrecht; California Institute of Technology; Deutsche Forschungsgemeinschaft; Alexander von Humboldt-Stiftung; National Science Foundation","keywords":"Golgi apparatus; Viscosity; Membrane; Control (management); Cell biology; Chemistry; Endoplasmic reticulum; Biophysics; Biology; Computer science; Physics; Biochemistry; Artificial intelligence; Thermodynamics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005301807,0.0001243527,0.0001952351,0.0002133985,0.0002845924,0.0001202078,0.001164539,0.00004583037,0.00004534419],"category_scores_gemma":[0.001455201,0.0001071328,0.00005641926,0.001748852,0.0009387544,0.0002059906,0.0002432172,0.00016506,0.00002244285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001009026,"about_ca_system_score_gemma":0.0002689182,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003061245,"about_ca_topic_score_gemma":0.000007669972,"domain_scores_codex":[0.9974113,0.00006392915,0.0002372798,0.0005653632,0.000848826,0.0008733287],"domain_scores_gemma":[0.9989246,0.000279448,0.0000374614,0.000327398,0.0001031253,0.0003279517],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004539894,0.00008856385,0.001652236,0.00001248703,0.000001825274,0.000003514357,0.0001722044,0.002421974,0.9878509,0.004402891,0.00002075136,0.003327271],"study_design_scores_gemma":[0.0003191609,0.00006568165,0.01682368,0.00002609489,0.000005276552,0.000001924992,0.0000153268,0.01554647,0.9666393,0.0001306108,0.0003230124,0.0001035022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907792,0.00002353163,0.003268685,0.0005181513,0.0003695732,0.0003678947,0.00001401088,0.00003639107,0.004622563],"genre_scores_gemma":[0.9990801,0.00002632658,0.0003014457,0.000438508,0.00002336862,0.000007450047,2.675108e-7,0.000005357424,0.0001171987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02121162,"threshold_uncertainty_score":0.4368747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02160857482239701,"score_gpt":0.3126459686158254,"score_spread":0.2910373937934284,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}