{"id":"W4413198560","doi":"10.1021/acsmedchemlett.5c00378","title":"A Nucleoside Analogue Featuring a C3′-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of <i>KRAS</i>-Mutated Pancreatic Cancer Cells","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Stereocenter; KRAS; Pancreatic cancer; Virology; Cancer research; Chemistry; Cancer; Biology; Medicine; Genetics; Biochemistry; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005881024,0.0002018038,0.0001363169,0.0001085761,0.0001222892,0.0001403872,0.0002125748,0.0003174861,0.001124958],"category_scores_gemma":[0.00006308177,0.00007578181,0.00009463707,0.000169644,0.0001255234,0.0001015201,0.00009611946,0.0002523414,0.0002144364],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002248492,"about_ca_system_score_gemma":0.0002222124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00149021,"about_ca_topic_score_gemma":0.001257497,"domain_scores_codex":[0.9999478,0.000008519574,0.00000503799,0.00001340501,0.00001198886,0.00001326553],"domain_scores_gemma":[0.9999641,0.000003953716,0.000009549546,0.000004280558,0.000003602973,0.00001449603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004129975,0.00003651185,0.000116563,0.00004607144,0.000008206299,0.0001194011,0.0000154806,0.000558946,0.9950427,0.0005118992,0.0001626415,0.002968639],"study_design_scores_gemma":[0.00003585008,0.0005911487,0.0006344777,0.000004752075,0.00001261351,0.0001406769,0.00001152612,0.0004847637,0.994031,0.00004655882,0.004001139,0.000005439672],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920123,0.001088518,0.0009569151,0.000115804,0.00005092862,0.0000296208,0.0004798798,0.00007272994,0.005193248],"genre_scores_gemma":[0.9969842,0.0003998755,0.0009530924,0.00005943018,0.000003449017,0.00001391346,0.0003651779,0.00001115789,0.001209618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00149021,"threshold_uncertainty_score":0.003763318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006436809705736438,"score_gpt":0.2521673949624722,"score_spread":0.2457305852567358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}