{"id":"W4413198560","doi":"10.1021/acsmedchemlett.5c00378","title":"A Nucleoside Analogue Featuring a C3′-Stereogenic All-Carbon Quaternary Center as a Bioenergetic Disruptor of <i>KRAS</i>-Mutated Pancreatic Cancer Cells","year":2025,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Glycomics Network; Canadian Institutes of Health Research; Terry Fox Research Institute","keywords":"Stereocenter; KRAS; Pancreatic cancer; Virology; Cancer research; Chemistry; Cancer; Biology; Medicine; Genetics; Biochemistry; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001296431,0.0003739428,0.0004685376,0.00006795492,0.00005162117,0.0000193375,0.0004010183,0.0002027522,0.00005520557],"category_scores_gemma":[0.00004678178,0.0003500583,0.0001840677,0.0002234476,0.0002326214,0.000006806913,0.0001630852,0.0002339876,0.000002430543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006957111,"about_ca_system_score_gemma":0.0001876933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001371095,"about_ca_topic_score_gemma":0.00006107137,"domain_scores_codex":[0.9980607,0.00005472344,0.0004638839,0.000610816,0.0002949902,0.0005148914],"domain_scores_gemma":[0.998972,0.00002415306,0.0002166666,0.0005182346,0.00008920727,0.0001797386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002990091,0.00008006862,0.002471988,0.0003851489,0.000515806,0.00001586169,0.0001281985,0.00004032873,0.9888949,9.00661e-7,0.006651779,0.0005160028],"study_design_scores_gemma":[0.001637819,0.00004780425,0.0009501949,0.0003564145,0.0004061532,0.00004855629,0.0001247883,0.00003280927,0.9795938,0.00000655455,0.0164809,0.0003142419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9917176,0.004717024,0.00004664764,0.001638121,0.0008806066,0.0002060988,0.00006031305,0.00002630611,0.0007073273],"genre_scores_gemma":[0.9930803,0.001919369,0.00006679081,0.002570326,0.001073576,0.0000738183,0.0002203911,0.00004275721,0.0009526846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009829121,"threshold_uncertainty_score":0.9998952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006436809705736438,"score_gpt":0.2521673949624722,"score_spread":0.2457305852567358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}