{"id":"W4413209860","doi":"10.1016/j.jddst.2025.107355","title":"Design and evaluation of complex plant extract-loaded dissolving microneedle for improving periocular wrinkles","year":2025,"lang":"en","type":"article","venue":"Journal of Drug Delivery Science and Technology","topic":"Skin Protection and Aging","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Institute of Physics; Chongqing Science and Technology Commission; Canadian Anesthesiologists' Society","keywords":"Materials science; Dissolution; Biomedical engineering; Wrinkle; Nanotechnology; Composite material; Medicine; Engineering; Chemical engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002132623,0.00005781353,0.0001795556,0.0006991781,0.0001675786,0.00002273321,0.00009099405,0.00004658021,0.000004960983],"category_scores_gemma":[0.0004284407,0.00004539514,0.00002013642,0.0003842677,0.0003720457,0.0001597137,0.00004684197,0.0001254725,9.011124e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005938398,"about_ca_system_score_gemma":0.0003461209,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000816892,"about_ca_topic_score_gemma":0.000001187176,"domain_scores_codex":[0.9992388,0.00001975231,0.0002420722,0.0001215207,0.000247962,0.0001299108],"domain_scores_gemma":[0.9988506,0.00007128056,0.0001916491,0.00007336626,0.0007768762,0.00003617013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005484049,0.00003121109,0.001472977,0.00004883051,0.00001522067,0.000003216044,0.000124025,0.00001334662,0.879637,0.0001091009,0.00004875968,0.1184415],"study_design_scores_gemma":[0.003458803,0.0004937325,0.009889939,0.0004966738,0.0003199519,0.0008118383,0.004735293,0.1106186,0.866384,0.002151694,0.0005188772,0.000120586],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987165,0.001893113,0.008879931,0.001646648,0.00008387553,0.0002946974,7.797128e-7,0.000009006545,0.00002696913],"genre_scores_gemma":[0.9903992,0.00007195097,0.009433976,0.00005858583,0.00001223712,0.000004354234,2.864894e-7,0.00000228507,0.00001709976],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1183209,"threshold_uncertainty_score":0.185116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0311969061228599,"score_gpt":0.2998095819582521,"score_spread":0.2686126758353922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}