{"id":"W4413236684","doi":"10.1016/j.imbio.2025.153039","title":"VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN","year":2025,"lang":"en","type":"article","venue":"Immunobiology","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Placebo; Double blind; Medicine; Internal medicine; Phases of clinical research; Pediatrics; Clinical trial; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001329974,0.001768488,0.002194403,0.0003856685,0.0005071834,0.001203508,0.0009403864,0.001909977,0.00645025],"category_scores_gemma":[0.001331746,0.0006343295,0.00150312,0.0003771046,0.00105397,0.00113241,0.0003728628,0.002642442,0.001086142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006673113,"about_ca_system_score_gemma":0.001372233,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000819123,"about_ca_topic_score_gemma":0.002139684,"domain_scores_codex":[0.9996473,0.0001737515,0.00001907072,0.00006905861,0.000028408,0.00006245033],"domain_scores_gemma":[0.9994648,0.0001186167,0.000148045,0.00003644734,0.00004770951,0.0001843546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9739251,0.005446841,0.0005588731,0.000705735,0.0007134171,0.00005283617,0.00005903532,0.0004079965,0.00375955,0.000246609,0.002235955,0.01188791],"study_design_scores_gemma":[0.9662793,0.03112576,0.0007540346,0.00002974968,0.0001573021,0.00003496202,0.000015476,0.0002342347,0.0002534885,0.0001423771,0.0009633834,0.000009808459],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9701129,0.007426764,0.001420587,0.001442742,0.0009759565,0.008867582,0.003443784,0.0005320915,0.005777707],"genre_scores_gemma":[0.9628031,0.005244963,0.0038745,0.003714766,0.0006221441,0.01169211,0.003613346,0.00008441453,0.008350627],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00645025,"threshold_uncertainty_score":0.02157819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006993482524139,"score_gpt":0.3166268624536568,"score_spread":0.2965569276284155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}