{"id":"W4413236684","doi":"10.1016/j.imbio.2025.153039","title":"VALIANT: Randomized, multicenter, double-blind, placebo-controlled, phase 3 trial of pegcetacoplan for patients with native or post-transplant recurrent C3G or primary (idiopathic) IC-MPGN","year":2025,"lang":"en","type":"article","venue":"Immunobiology","topic":"Pituitary Gland Disorders and Treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Placebo; Double blind; Medicine; Internal medicine; Phases of clinical research; Pediatrics; Clinical trial; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005339494,0.0004123161,0.002161991,0.0002732819,0.0001364597,0.00001200663,0.0001749464,0.0002277502,0.00007677425],"category_scores_gemma":[0.0003069129,0.000208376,0.0004174365,0.0001684608,0.0002551406,0.00008031669,0.00003682716,0.0002111018,0.000006464806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009017254,"about_ca_system_score_gemma":0.0005546144,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001246769,"about_ca_topic_score_gemma":0.0001071631,"domain_scores_codex":[0.9976199,0.000305567,0.0009822078,0.0004731246,0.0001775084,0.0004416895],"domain_scores_gemma":[0.9976854,0.001055074,0.0004162502,0.0003539845,0.000398993,0.00009035322],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9828378,0.007721722,0.001108449,0.0003989858,0.003366372,0.00004725645,0.0005318782,7.302054e-7,0.0001751532,0.00007982977,0.00007398408,0.003657822],"study_design_scores_gemma":[0.9770559,0.01839472,0.0001708587,0.0006244965,0.002354569,0.00001818906,0.0001230357,0.00003262324,0.0003595205,0.00003096895,0.0006185517,0.0002165417],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9761736,0.003224263,0.0005367787,0.0003295314,0.001388936,0.01664551,0.0008340525,0.00004786554,0.0008194403],"genre_scores_gemma":[0.9929258,0.001046753,0.0002801792,0.0002953466,0.0000676659,0.001945953,0.002409671,0.00002709554,0.001001532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01675218,"threshold_uncertainty_score":0.8497326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02006993482524139,"score_gpt":0.3166268624536568,"score_spread":0.2965569276284155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}