{"id":"W4413247654","doi":"10.2139/ssrn.5380705","title":"Safety and Immunogenicity of Covac-2, a Sepivac Swe™ Adjuvanted Sars-Cov-2 Recombinant Protein Vaccine in Healthy Adults; a Randomized Controlled First-in-Human Dose-Escalation Trial","year":2025,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Dalhousie University; University of Saskatchewan","funders":"","keywords":"Immunogenicity; Medicine; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Coronavirus disease 2019 (COVID-19); Virology; Recombinant DNA; 2019-20 coronavirus outbreak; Immunology; Biology; Antibody; Internal medicine; Outbreak; Infectious disease (medical specialty); Gene; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001878949,0.001890165,0.002379256,0.0002855302,0.0003598953,0.001155935,0.0005874674,0.002204084,0.003646481],"category_scores_gemma":[0.001691096,0.0006790422,0.001607349,0.0002859416,0.00118766,0.001264505,0.0003165238,0.002656874,0.0008989221],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000674116,"about_ca_system_score_gemma":0.0008470285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005181901,"about_ca_topic_score_gemma":0.000494695,"domain_scores_codex":[0.9991605,0.0004049182,0.00004833651,0.0001745993,0.00006971054,0.0001419172],"domain_scores_gemma":[0.9992575,0.00017691,0.0001842445,0.00008684663,0.00006509656,0.0002293633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9765648,0.006139868,0.001072802,0.0002293432,0.0006979505,0.00003207721,0.00004800733,0.0002550673,0.003444964,0.0000613954,0.0004372437,0.0110164],"study_design_scores_gemma":[0.7348247,0.2542029,0.006760386,0.00004304763,0.0009966901,0.00005172341,0.00004117584,0.0006288067,0.001266669,0.0002443531,0.000908596,0.00003090364],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994916,0.002179584,0.0003274065,0.0002267959,0.0001867468,0.0008591072,0.0004756469,0.0000341954,0.0007945606],"genre_scores_gemma":[0.9933239,0.001237846,0.0005614212,0.0006948899,0.0002927143,0.001166323,0.0007929635,0.00001807408,0.001911913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003646481,"threshold_uncertainty_score":0.01219875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716213618105138,"score_gpt":0.3368477779233876,"score_spread":0.3196856417423362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}