{"id":"W4413250635","doi":"10.3390/life15081256","title":"Adverse Events and Drug Interactions Associated with Elexacaftor/Tezacaftor/Ivacaftor Treatment: A Descriptive Study Across Australian, Canadian, and American Adverse Event Databases","year":2025,"lang":"en","type":"article","venue":"Life","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Adverse Event Reporting System; Adverse effect; Database; Medicine; Polypharmacy; Ivacaftor; Pharmacology; Internal medicine; Cystic fibrosis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001713735,0.0003124874,0.0005106831,0.0002496291,0.0003136011,0.00002167574,0.00009564356,0.00002601837,0.0001237069],"category_scores_gemma":[0.00103128,0.0002519355,0.00005785211,0.0005479201,0.0002622059,0.0003184809,0.0001003985,0.0002599837,0.00001751803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00106029,"about_ca_system_score_gemma":0.0007767626,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.1120662,"about_ca_topic_score_gemma":0.08221227,"domain_scores_codex":[0.9979831,0.000162213,0.0003184753,0.0005718137,0.0003366215,0.0006277848],"domain_scores_gemma":[0.9981618,0.0003185445,0.0001357681,0.0003704379,0.000171672,0.0008417674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001067831,0.0009385984,0.9887341,0.00005285693,0.0011292,0.0002319265,0.0006586499,0.0000127073,0.0002761357,0.00001131573,0.00461241,0.002274271],"study_design_scores_gemma":[0.004247853,0.001074696,0.9204831,0.0005346721,0.0003305803,0.00001695213,0.02744996,0.0000791722,0.0001339775,0.000004033874,0.04541721,0.0002278606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963337,0.0001323721,0.0000107378,0.000510841,0.00002607286,0.001389702,0.001363948,0.00006023439,0.0001724026],"genre_scores_gemma":[0.9867772,0.00006139107,0.0003509301,0.0002360531,0.00005162455,0.0002403776,0.0002538553,0.00002741715,0.01200111],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06825107,"threshold_uncertainty_score":0.9999933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03240107400841925,"score_gpt":0.3671184177142006,"score_spread":0.3347173437057813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}