{"id":"W4413250635","doi":"10.3390/life15081256","title":"Adverse Events and Drug Interactions Associated with Elexacaftor/Tezacaftor/Ivacaftor Treatment: A Descriptive Study Across Australian, Canadian, and American Adverse Event Databases","year":2025,"lang":"en","type":"article","venue":"Life","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Adverse Event Reporting System; Adverse effect; Database; Medicine; Polypharmacy; Ivacaftor; Pharmacology; Internal medicine; Cystic fibrosis","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005303623,0.0001570491,0.0005862349,0.006637019,0.0006057356,0.001098979,0.0006623489,0.0002849898,0.001081829],"category_scores_gemma":[0.02184087,0.0001774222,0.000714177,0.01009631,0.0003769093,0.0008020457,0.0009608836,0.0004025662,0.0001208954],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002371367,"about_ca_system_score_gemma":0.004130493,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.1197161,"about_ca_topic_score_gemma":0.1704192,"domain_scores_codex":[0.9913776,0.001462928,0.003145243,0.0007766979,0.002873222,0.0003642326],"domain_scores_gemma":[0.9585343,0.01226883,0.02172146,0.001151237,0.005464444,0.000859788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004193225,0.00005619405,0.96618,0.002778219,0.0003876062,0.0004651079,0.001447001,0.0001211711,0.000213965,0.0002967187,0.002244347,0.02539033],"study_design_scores_gemma":[0.00001404799,0.00007226947,0.9915085,0.0005460387,0.0001848379,0.00102138,0.001125531,0.0001880734,0.0001468992,0.00005195535,0.005122392,0.0000181459],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9233476,0.02117825,0.0009451903,0.0006771925,0.00002391157,0.0008717235,0.04677293,0.0000412107,0.006142016],"genre_scores_gemma":[0.9673399,0.01232608,0.001670522,0.0004480321,0.00002790395,0.0006015661,0.01676909,0.00001539093,0.0008015177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8802839,"threshold_uncertainty_score":0.2380385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03240107400841925,"score_gpt":0.3671184177142006,"score_spread":0.3347173437057813,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}