{"id":"W4413257137","doi":"10.1021/acs.jproteome.5c00523","title":"Podocyte Proteomics Revealed hUCMSC-Exosomes Ameliorate Diabetic Kidney Disease through Inhibiting Talin-1 Mediated EMT","year":2025,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Natural Science Foundation of China","keywords":"Podocyte; Microvesicles; Mesenchymal stem cell; Medicine; Oxidative stress; Cancer research; Kidney; Apoptosis; Downregulation and upregulation; Proteomics; Cell biology; Internal medicine; Chemistry; Proteinuria; Pathology; Biology; microRNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001662999,0.000252987,0.0002467315,0.00033316,0.0001511349,0.0002113791,0.0001088056,0.0002351318,0.00106985],"category_scores_gemma":[0.00008975377,0.00006990162,0.0002982185,0.0001934751,0.0001616367,0.0002424967,0.0001940603,0.0004273179,0.0001717103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001798621,"about_ca_system_score_gemma":0.0002010918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002836375,"about_ca_topic_score_gemma":0.0004283091,"domain_scores_codex":[0.9998832,0.00001151989,0.00001269751,0.00002636702,0.00004024795,0.00002582992],"domain_scores_gemma":[0.999931,0.000006138165,0.00001965142,0.00000460234,0.00001768572,0.00002094082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001911435,0.00003231844,0.0005202217,0.00005792364,0.00001020931,0.00003857461,0.00001211008,0.00003423138,0.997436,0.00006532834,0.00007655683,0.00152537],"study_design_scores_gemma":[0.00001204649,0.0001346374,0.009976685,0.000008859026,0.00003216368,0.0001649845,0.00003175451,0.0007437412,0.9876822,0.00005423417,0.001154871,0.000003830217],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907048,0.001381573,0.005675287,0.0001797148,0.00005860144,0.00003311057,0.001030795,0.0001271234,0.000808829],"genre_scores_gemma":[0.9902827,0.001094505,0.00474321,0.0001555414,0.00001603653,0.00004719899,0.001153284,0.00003152438,0.002475942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00106985,"threshold_uncertainty_score":0.003578961,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03137507902882158,"score_gpt":0.3621383778828101,"score_spread":0.3307632988539885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}