{"id":"W4413258163","doi":"10.1080/15287394.2025.2545425","title":"Identification of individuals at higher risk of airway obstruction among workers in swine operations using polygenic risk scores","year":2025,"lang":"en","type":"article","venue":"Journal of Toxicology and Environmental Health","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Alberta; Memorial University of Newfoundland","funders":"Canadian Institutes of Health Research","keywords":"Logistic regression; Medicine; Confounding; Single-nucleotide polymorphism; Airway obstruction; Internal medicine; Airway; Surgery; Biology; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008537353,0.0003668967,0.0003220405,0.0007123133,0.0004556178,0.0004509737,0.0001784027,0.0003959619,0.0008798318],"category_scores_gemma":[0.001328317,0.0001612632,0.0005642429,0.0005812113,0.0002885393,0.000213576,0.0004603364,0.0003685851,0.0001340653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020022,"about_ca_system_score_gemma":0.0002495412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002028867,"about_ca_topic_score_gemma":0.003955312,"domain_scores_codex":[0.9995159,0.0001915233,0.00003642182,0.0001107685,0.00006810867,0.00007722083],"domain_scores_gemma":[0.9991338,0.000233122,0.0003609122,0.00008391528,0.00006832655,0.0001200171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00009225601,0.00003411667,0.9956988,0.000006817557,0.00005899932,0.00007807834,0.00009526045,0.0001324422,0.001361955,0.00002091583,0.00003196198,0.002388379],"study_design_scores_gemma":[0.000002297527,0.00009921057,0.9982941,0.000004396285,0.00003712858,0.0001092394,0.0001645403,0.0009992396,0.0001219347,0.00008347097,0.00008052943,0.000003873907],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991902,0.00006921649,0.0005657982,0.00002352689,0.000003100739,0.000003548095,0.00004100992,0.000002432995,0.0001012684],"genre_scores_gemma":[0.9994531,0.00003314174,0.0003105619,0.000008394398,0.000003792231,0.000003498038,0.00007236565,0.000001127583,0.0001140305],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002028867,"threshold_uncertainty_score":0.004514992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01052055705504039,"score_gpt":0.2560282181780814,"score_spread":0.245507661123041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}