{"id":"W4413258410","doi":"10.1038/s42003-025-08675-8","title":"Predictive capabilities of polygenic scores in an East-Asian population-based cohort: the Singapore Chinese health study","year":2025,"lang":"en","type":"article","venue":"Communications Biology","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; Cancer Science Institute of Singapore, National University of Singapore; Medical Research Council; University of Pittsburgh; Medical Center, University of Pittsburgh; National University Health System; University of Melbourne; Singapore Eye Research Institute; National Institutes of Health; National Cancer Institute; National Medical Research Council; National University of Singapore; Genome Institute of Singapore; National Cancer Centre of Singapore; Agency for Science, Technology and Research; Duke-NUS Medical School","keywords":"Chinese population; Cohort; Demography; East Asia; Polygenic risk score; Medicine; Geography; Psychology; China; Genetics; Internal medicine; Biology; Sociology; Genotype; Gene; Single-nucleotide polymorphism","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003672474,0.0006819967,0.0003767598,0.0008699972,0.0003679238,0.0007567411,0.0003046728,0.0003398287,0.0007903377],"category_scores_gemma":[0.005345218,0.0001919116,0.0007563517,0.001157157,0.0003738412,0.000317985,0.000826989,0.0005531542,0.0001522728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002468518,"about_ca_system_score_gemma":0.0004148018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01124874,"about_ca_topic_score_gemma":0.009693786,"domain_scores_codex":[0.9990075,0.0004829638,0.00008896548,0.0002025856,0.0001429337,0.00007502891],"domain_scores_gemma":[0.9964877,0.001198074,0.0007964092,0.000760929,0.0003757735,0.0003811526],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001124018,0.000009352272,0.997398,0.000005581509,0.0001927212,0.00005699479,0.00007402085,0.000238796,0.0001642846,0.0000313755,0.00007369508,0.001642642],"study_design_scores_gemma":[0.00000808297,0.00003578519,0.9978201,0.000003688557,0.00008107624,0.00007482718,0.00005368746,0.001678111,0.00006875021,0.0000761137,0.00009338861,0.000006303596],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988486,0.00009440092,0.0003251703,0.00004066957,0.000004918666,0.000006138308,0.0004347784,0.000007295833,0.0002380947],"genre_scores_gemma":[0.9991882,0.00004553541,0.0001591254,0.00001317459,0.000005984155,0.000005694975,0.0005158903,0.000002733409,0.00006354655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01124874,"threshold_uncertainty_score":0.02236652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01906183439711506,"score_gpt":0.3481886488936339,"score_spread":0.3291268144965188,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}