{"id":"W4413268582","doi":"10.1016/j.atherosclerosis.2025.120374","title":"Zodasiran (ARO-ANG3), an investigational RNAi therapeutic, demonstrates profound and durable reductions in LDL-cholesterol, apolipoprotein B, and ANGPTL3 in patients with HoFH; gateway final results","year":2025,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi; Université Laval; Western University; Centre hospitalier de l'Université Laval","funders":"","keywords":"Apolipoprotein B; Medicine; Cholesterol; Ldl cholesterol; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004107355,0.0005678572,0.0004396549,0.0001959157,0.0003028686,0.0003671442,0.0004257159,0.0006482457,0.003049487],"category_scores_gemma":[0.0001384084,0.0001543513,0.0004609087,0.0001124358,0.0004160643,0.0001881988,0.0002323312,0.001280864,0.0005008376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004214668,"about_ca_system_score_gemma":0.0006613709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001161931,"about_ca_topic_score_gemma":0.003069363,"domain_scores_codex":[0.9998622,0.00002020373,0.000008391052,0.00002275187,0.00004296799,0.000043622],"domain_scores_gemma":[0.999935,0.00000862234,0.00001075471,0.000006992673,0.000008660877,0.00002992975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.008315644,0.001669921,0.002905825,0.0002944267,0.0002154232,0.001664361,0.00007426064,0.0003034705,0.893739,0.002522599,0.01014306,0.0781521],"study_design_scores_gemma":[0.00830547,0.01439735,0.02274903,0.0000569208,0.0006253462,0.004652014,0.0001606832,0.00155157,0.8765113,0.001041058,0.0698804,0.0000687889],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9300883,0.008160139,0.01847567,0.005844829,0.0007540352,0.001070369,0.00352628,0.001428673,0.03065172],"genre_scores_gemma":[0.9681673,0.003897117,0.01003037,0.001659825,0.0001369216,0.0003871293,0.002384623,0.0001006399,0.01323611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003049487,"threshold_uncertainty_score":0.01020157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469352032040275,"score_gpt":0.2534026133126022,"score_spread":0.2387090929921995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}