{"id":"W4413268582","doi":"10.1016/j.atherosclerosis.2025.120374","title":"Zodasiran (ARO-ANG3), an investigational RNAi therapeutic, demonstrates profound and durable reductions in LDL-cholesterol, apolipoprotein B, and ANGPTL3 in patients with HoFH; gateway final results","year":2025,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Université du Québec à Chicoutimi; Université Laval; Western University; Centre hospitalier de l'Université Laval","funders":"","keywords":"Apolipoprotein B; Medicine; Cholesterol; Ldl cholesterol; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002689758,0.0002078432,0.000175867,0.000175105,0.0001377979,0.00009406657,0.0001342637,0.0002049811,0.00000427594],"category_scores_gemma":[0.00005682968,0.000196725,0.00002416205,0.0003411429,0.0002756017,0.00003075646,0.00008474295,0.0002317851,9.915274e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005404737,"about_ca_system_score_gemma":0.000159829,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005176025,"about_ca_topic_score_gemma":0.001429609,"domain_scores_codex":[0.9984525,0.0001517916,0.0002792829,0.0005859767,0.0001930803,0.0003373016],"domain_scores_gemma":[0.9994029,0.00001507989,0.00007202471,0.0003146325,0.0000911212,0.0001042411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001281108,0.0004991776,0.1074197,0.0000592701,0.0001119666,0.00000186362,0.0003908691,0.0002909387,0.8812934,0.0003826805,0.0001050488,0.008164042],"study_design_scores_gemma":[0.005565075,0.001070566,0.8100708,0.0002188609,0.00002554559,0.000003744093,0.0001717094,0.0002030306,0.1813226,0.0007336703,0.0003109789,0.000303497],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980667,0.0002434846,0.0002523776,0.0005442962,0.00003714179,0.0006653335,0.00004787037,0.00001226699,0.0001304771],"genre_scores_gemma":[0.9982856,0.0001730334,0.0007365811,0.0002288449,0.0000252175,0.0001393462,0.0001315059,0.00002754134,0.0002523567],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7026511,"threshold_uncertainty_score":0.8022214,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01469352032040275,"score_gpt":0.2534026133126022,"score_spread":0.2387090929921995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}