{"id":"W4413284393","doi":"10.1093/ijnp/pyaf052.187","title":"221. NEUROMELANIN ACCUMULATION AND TREATMENT RESPONSIVENESS IN PATIENTS WITH SCHIZOPHRENIA: A CROSS-SECTIONAL STUDY WITH NEUROMELANIN-SENSITIVE MRI","year":2025,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Rehabilitation Institute; University of Toronto; Centre for Addiction and Mental Health","funders":"","keywords":"Neuromelanin; Medicine; Schizophrenia (object-oriented programming); Cross-sectional study; Psychiatry; Psychology; Neuroscience; Internal medicine; Pathology; Parkinson's disease; Disease; Substantia nigra","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005034597,0.0003074545,0.0002889401,0.0007544567,0.000571368,0.0004127952,0.0001683942,0.0005816799,0.00146467],"category_scores_gemma":[0.0007714443,0.0003237317,0.0003309358,0.0004552357,0.0002861316,0.0004566357,0.0003882526,0.0003858781,0.000407804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001829331,"about_ca_system_score_gemma":0.0001835716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001162888,"about_ca_topic_score_gemma":0.001955983,"domain_scores_codex":[0.9997442,0.00006450291,0.00003549567,0.00008987461,0.00003169631,0.00003421757],"domain_scores_gemma":[0.9994296,0.00007637808,0.0002429185,0.00004520619,0.00006551775,0.0001403241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001846958,0.0001495059,0.997311,0.00001338697,0.0000566786,0.0001117783,0.0001744526,0.00001562401,0.001157823,0.000007950484,0.00002673934,0.0007903731],"study_design_scores_gemma":[0.0000077022,0.0004026034,0.9986014,0.000003009619,0.00002969877,0.0004134479,0.0002541726,0.00005512896,0.0001072364,0.00001024282,0.000111152,0.000004190721],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995902,0.0001186832,0.00004587407,0.00001173925,0.000002807039,0.000009579152,0.0000839328,0.000001442902,0.0001356738],"genre_scores_gemma":[0.9996002,0.00005022711,0.00007783334,0.00002100904,0.000004860651,0.00001262675,0.0001206749,9.322922e-7,0.0001115724],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00146467,"threshold_uncertainty_score":0.0048998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01416049769878057,"score_gpt":0.3327741350401433,"score_spread":0.3186136373413627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}