{"id":"W4413285028","doi":"10.1093/ijnp/pyaf052.305","title":"521. L655,708 A NEGATIVE ALLOSTERIC MODULATOR AT OF GABAA RECEPTOR INCREASED DOPAMINE NEURONAL ACTIVITY UP TO 1 WEEK AFTER A SINGLE INJECTION","year":2025,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"","keywords":"GABAA receptor; Allosteric regulation; Allosteric modulator; Neuroscience; Dopamine; Receptor; Chemistry; Dopamine receptor; Pharmacology; Psychology; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001094023,0.0005057346,0.0006764028,0.0002930564,0.0001718171,0.0002645383,0.0003181703,0.0004409706,0.005692683],"category_scores_gemma":[0.0001214367,0.0001568094,0.0002796687,0.0002109502,0.0003514557,0.0003120661,0.0001498751,0.001239071,0.001147934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002765405,"about_ca_system_score_gemma":0.0003626516,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001147199,"about_ca_topic_score_gemma":0.002305122,"domain_scores_codex":[0.9998134,0.00001862797,0.00002007131,0.0000413921,0.00003481694,0.00007177373],"domain_scores_gemma":[0.9998761,0.00001428793,0.00003459878,0.00001342918,0.00001891886,0.00004260449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00305656,0.0008405386,0.0002165304,0.0001241845,0.00002321246,0.0001112103,0.00004757173,0.00006364861,0.9890541,0.000121363,0.0004649241,0.005876163],"study_design_scores_gemma":[0.0005697615,0.02221613,0.007794415,0.00003411407,0.00009872778,0.0003573939,0.000129821,0.0009759986,0.9634269,0.0001085721,0.004263631,0.00002458295],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919937,0.001271475,0.00107632,0.0002789561,0.0002025105,0.0001068887,0.001425581,0.0002764753,0.003368156],"genre_scores_gemma":[0.9850921,0.000947,0.001344231,0.0001946786,0.00005248665,0.0001948218,0.001344425,0.00003143778,0.01079879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005692683,"threshold_uncertainty_score":0.01904392,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04137523624345569,"score_gpt":0.3572231069984905,"score_spread":0.3158478707550348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}