{"id":"W4413285232","doi":"10.2340/actadv.v105.43608","title":"In Vitro Evidence Demonstrating the Nondepleting Mechanism of Action of Amlitelimab, an OX40 Ligand Monoclonal Antibody","year":2025,"lang":"en","type":"article","venue":"Acta Dermato Venereologica","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Eli Lilly Japan; Allergan; LEO Pharma; Otsuka Pharmaceutical; Valeant Pharmaceuticals International; Incyte; Taiho Pharmaceutical; Sun Pharma; Regeneron Pharmaceuticals; Teva Pharmaceutical Industries; Biogen; Gilead Sciences; Sanofi; Amgen; Pfizer; Galderma; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb","keywords":"Medicine; Monoclonal antibody; In vitro; Mechanism of action; Monoclonal; Antibody; Ligand (biochemistry); Immunology; Pharmacology; Receptor; Biochemistry; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004850948,0.0004262355,0.0002218699,0.0003200349,0.0002251328,0.0003752465,0.0004264015,0.0003744428,0.004048673],"category_scores_gemma":[0.0005982977,0.0001324243,0.0002725041,0.0001026297,0.0002300349,0.0002268365,0.0001979453,0.0006101863,0.0007998763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003081935,"about_ca_system_score_gemma":0.0004644211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008479026,"about_ca_topic_score_gemma":0.0006787511,"domain_scores_codex":[0.9996363,0.00009973298,0.00002413824,0.00003330241,0.0001256653,0.00008079736],"domain_scores_gemma":[0.9996679,0.0001399045,0.0000432716,0.00003983661,0.00006812124,0.00004092601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000374491,0.0002746582,0.0003878628,0.0002200614,0.00001709549,0.0003562999,0.00005365976,0.000121186,0.9864085,0.001556286,0.0003728427,0.009857049],"study_design_scores_gemma":[0.0001650773,0.00209744,0.004430673,0.00002888325,0.00006821455,0.002204694,0.00004833562,0.001146487,0.9729163,0.0004493813,0.01643685,0.000007730218],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9434679,0.01387921,0.017101,0.0008034296,0.0003444107,0.0002005655,0.0005858781,0.0001776288,0.02344003],"genre_scores_gemma":[0.9825105,0.00389517,0.003537653,0.0002543849,0.0001120844,0.00009845269,0.0006638883,0.00001335415,0.008914561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004048673,"threshold_uncertainty_score":0.01354414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06221951136599271,"score_gpt":0.3913705956513461,"score_spread":0.3291510842853534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}