{"id":"W4413285315","doi":"10.1186/s12967-025-06826-3","title":"In depth characterisation of the proteome of MIS-C and post COVID-19 infection in children reveals inflammatory pathway activation and evidence of tissue damage","year":2025,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Kawasaki Disease and Coronary Complications","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Public Health Agency; Northern Ireland Chest Heart and Stroke; Hospital for Sick Children; Queen's University Belfast","keywords":"Coronavirus disease 2019 (COVID-19); Proteome; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); 2019-20 coronavirus outbreak; Inflammation; Coronavirus Infections; Medicine; Computational biology; Immunology; Biology; Bioinformatics; Virology; Pathology; Outbreak","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005062704,0.00006613397,0.0002609602,0.0003753142,0.00001971341,0.00000132508,0.0000472395,0.00004738696,0.00001745811],"category_scores_gemma":[0.0005298686,0.00004723198,0.00002948694,0.0003222028,0.0001247202,0.0002219616,0.000006807365,0.0001345471,3.543843e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003879286,"about_ca_system_score_gemma":0.0003237494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001482637,"about_ca_topic_score_gemma":0.0000383822,"domain_scores_codex":[0.9988585,0.00009815395,0.0006654954,0.00007811491,0.0002521171,0.00004766017],"domain_scores_gemma":[0.9989423,0.0002280243,0.0004676079,0.00009593039,0.0002171277,0.00004902169],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003862421,0.0000754756,0.6757491,0.0004843519,0.0000245821,7.488163e-7,0.0005427277,0.00003780478,0.3210658,0.0002468216,0.000007983832,0.001378401],"study_design_scores_gemma":[0.001738701,0.0002625506,0.9837451,0.002770702,0.00006790701,0.00003377237,0.0000513924,0.00004623309,0.01033552,0.0009028523,0.00001659793,0.00002866968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858672,0.000869061,0.000579257,0.01208637,0.00002585291,0.000531663,0.000005132487,0.000001419294,0.00003402019],"genre_scores_gemma":[0.9993423,0.000201843,0.0001072987,0.0002751744,0.00004137802,0.000006967129,0.000006886135,0.000003256018,0.00001494377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3107303,"threshold_uncertainty_score":0.1926064,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02199708955448395,"score_gpt":0.3264764607474749,"score_spread":0.304479371192991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}