{"id":"W4413286557","doi":"10.1111/all.70016","title":"Multi‐Ancestry Epigenome‐Wide Association Study of Asthma Exacerbations","year":2025,"lang":"en","type":"letter","venue":"Allergy","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"Fundación Canaria Instituto de Investigación Sanitaria de Canarias; European Social Fund; National Heart, Lung, and Blood Institute; Agencia Estatal de Investigación; New York Genome Center; Broad Institute; European Regional Development Fund; American Asthma Foundation; Robert Wood Johnson Foundation; Instituto de Salud Carlos III; Sandler Foundation; Ministerio de Ciencia, Innovación y Universidades; National Institute on Minority Health and Health Disparities; Tobacco-Related Disease Research Program","keywords":"Epigenome; Asthma; Medicine; Association (psychology); Genome-wide association study; Immunology; Genetics; Biology; DNA methylation; Single-nucleotide polymorphism; Genotype; Psychology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002094911,0.000241569,0.0003002035,0.0001104388,0.00008065494,0.00002282775,0.0002727146,0.0008359762,0.00003415857],"category_scores_gemma":[0.0003297131,0.0002640663,0.0001335663,0.0001377287,0.00001946492,0.000002621347,0.0001278594,0.0003794794,0.000005944023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006175051,"about_ca_system_score_gemma":0.0001530323,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001811747,"about_ca_topic_score_gemma":0.0004382033,"domain_scores_codex":[0.9983358,0.0001977204,0.00044822,0.000473413,0.0002899583,0.0002548928],"domain_scores_gemma":[0.9986166,0.0001129971,0.0004264666,0.0005387753,0.0002756304,0.00002949783],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003140141,0.0006813549,0.04116193,0.0001366449,0.001606886,0.00001867923,0.0002819124,0.001219481,0.02449948,0.000006090005,0.9289095,0.001446644],"study_design_scores_gemma":[0.0006334431,0.0003325412,0.01697242,0.00002249179,0.00004265827,6.019713e-8,0.00005701142,0.00001776934,0.004789765,0.00003844596,0.9768313,0.0002621434],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8147666,0.01177202,0.00638513,0.1487731,0.003538224,0.002598157,0.0005085008,0.00008723686,0.01157101],"genre_scores_gemma":[0.5688347,0.007857146,0.005739928,0.2111666,0.008827562,0.0006475251,0.01347642,0.0003201906,0.1831299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2459319,"threshold_uncertainty_score":0.9999812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01999506167128035,"score_gpt":0.2773541207315126,"score_spread":0.2573590590602323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}