{"id":"W4413288595","doi":"10.21203/rs.3.rs-7124496/v1","title":"Complex genetic architecture underlies human hand and foot evolution","year":2025,"lang":"en","type":"preprint","venue":"Research Square","topic":"Genetics and Physical Performance","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"University of Washington; National Institutes of Health; Harvard University; National Science Foundation","keywords":"Genetic architecture; Foot (prosody); Architecture; Cognitive science; Evolutionary biology; Biology; Neuroscience; Computer science; Psychology; History; Genetics; Philosophy; Gene; Phenotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003014372,0.0004223367,0.000388241,0.0007692926,0.0003085798,0.0009508541,0.0005051722,0.0007743691,0.002863848],"category_scores_gemma":[0.001374424,0.0003762033,0.0002619125,0.0007114965,0.001429595,0.000541487,0.0006490088,0.0006639536,0.0003524389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003549982,"about_ca_system_score_gemma":0.0004028597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002306661,"about_ca_topic_score_gemma":0.002981526,"domain_scores_codex":[0.9996681,0.00005452336,0.00001344883,0.0001480824,0.00007411493,0.00004167888],"domain_scores_gemma":[0.9994441,0.000226018,0.0001279084,0.00008504363,0.00005994373,0.00005697397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008071146,0.0002047239,0.1741101,0.0002197943,0.0003611771,0.004558074,0.00121304,0.03363558,0.6175802,0.05637801,0.001418424,0.1095137],"study_design_scores_gemma":[0.00008928683,0.0002481356,0.7769289,0.00007954115,0.0002429488,0.005685466,0.0004783929,0.05949928,0.04176182,0.1101528,0.004682007,0.0001514695],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9685186,0.0005001442,0.02629978,0.0003600238,0.00002259269,0.00001348684,0.0003159801,0.0001367987,0.003832565],"genre_scores_gemma":[0.9944713,0.0001679987,0.003967084,0.0000431847,0.00001677108,0.000007319813,0.00009867612,0.00004055886,0.001187215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002863848,"threshold_uncertainty_score":0.009580553,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04985337528881614,"score_gpt":0.3759207487182525,"score_spread":0.3260673734294364,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}