{"id":"W4413289215","doi":"10.1016/j.microb.2025.100509","title":"Breaking Staphylococcus aureus biofilms with the antimicrobial lipopeptide humimycin and its synthetic analogs","year":2025,"lang":"en","type":"article","venue":"The Microbe","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fonds de recherche du Québec – Nature et technologies; Natural Sciences and Engineering Research Council of Canada","keywords":"Lipopeptide; Staphylococcus aureus; Antimicrobial; Microbiology; Biofilm; Biology; Chemistry; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002253659,0.0001979505,0.0001543983,0.00003535161,0.0003520707,0.0001016895,0.0002609479,0.0001090624,0.000008220975],"category_scores_gemma":[0.00001932769,0.0001064875,0.00005920154,0.0001480983,0.0002070908,0.000004031041,0.0002363964,0.0001401445,0.000006633341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008497859,"about_ca_system_score_gemma":0.00005687374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001080236,"about_ca_topic_score_gemma":0.0002234674,"domain_scores_codex":[0.9990816,0.00009531895,0.0001474146,0.0003230372,0.00005174314,0.0003008713],"domain_scores_gemma":[0.9994066,0.00002536014,0.00007691212,0.0004011785,0.00005770162,0.0000322797],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001098114,0.00001665216,0.00008783919,0.00001657446,0.00008214666,0.000002670793,0.00007712172,0.000009343515,0.993647,0.0001441533,0.004232048,0.001574591],"study_design_scores_gemma":[0.0003605471,0.00007845973,0.0009952203,0.00006723334,0.00006997043,0.00003555816,0.00009024548,0.00001292419,0.9462285,0.000004542352,0.05188485,0.0001719266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944782,0.001201561,0.00005267312,0.0030595,0.0001405258,0.0002670847,0.00002979237,0.00001616633,0.0007545438],"genre_scores_gemma":[0.9966986,0.0001420112,0.0001343811,0.001908884,0.0001538814,0.000004415141,0.00002314985,0.00001975709,0.0009149478],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04765281,"threshold_uncertainty_score":0.4342435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004936471392634948,"score_gpt":0.2107040150499165,"score_spread":0.2057675436572816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}