{"id":"W4413292220","doi":"10.1016/j.cct.2025.108048","title":"Adaptive phase 2/3 design with dose optimization","year":2025,"lang":"en","type":"article","venue":"Contemporary Clinical Trials","topic":"Engineering Applied Research","field":"Engineering","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Victoria","funders":"U.S. Food and Drug Administration; Canada Excellence Research Chairs, Government of Canada; Canada Research Chairs; Michael Smith Health Research BC","keywords":"Medicine; Phase (matter); Research design; Medical physics; Statistics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007376085,0.0002124638,0.0008169077,0.0001719053,0.0000468648,0.00005736999,0.0002428954,0.0002165432,0.00006094774],"category_scores_gemma":[0.002315561,0.0001685055,0.0001475919,0.0004527475,0.00009357453,0.0001377343,0.00003737151,0.0004575022,0.00003642216],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004475306,"about_ca_system_score_gemma":0.0002260375,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002614813,"about_ca_topic_score_gemma":2.418595e-7,"domain_scores_codex":[0.9972654,0.0007817177,0.001202898,0.0003056823,0.0002006207,0.0002436879],"domain_scores_gemma":[0.993495,0.005767135,0.0000925129,0.0003969794,0.00008941014,0.0001589755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00163843,0.0001916216,0.00005894445,0.00005839573,0.0004867796,0.00003950551,0.0000211541,0.9428672,0.0003327949,0.0006805958,0.03170879,0.02191575],"study_design_scores_gemma":[0.0141602,0.0006897497,0.00006489668,0.0002391458,0.00007035916,0.000001278711,0.00004460098,0.9722562,0.002714976,0.0004053227,0.008980186,0.0003731087],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.0009420207,0.001252761,0.9792491,0.0001948641,0.000560624,0.001342726,0.00001595648,0.0006365082,0.01580543],"genre_scores_gemma":[0.9526659,0.0002611807,0.0458567,0.00009969664,0.000272728,0.0001909411,0.00002205052,0.00005700692,0.0005737835],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.9517239,"threshold_uncertainty_score":0.6871455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4298548589172028,"score_gpt":0.4895050882261288,"score_spread":0.05965022930892594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}