{"id":"W4413293782","doi":"10.1016/j.sbi.2025.103134","title":"Functional sub-states link conformational landscapes and protein evolution","year":2025,"lang":"en","type":"review","venue":"Current Opinion in Structural Biology","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Michael Smith Health Research BC; Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"Japan Society for the Promotion of Science; Helse Nord RHF; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Federation of European Biochemical Societies; Natural Sciences and Engineering Research Council of Canada; Universitetet i Tromsø; Federation of European Microbiological Societies; Human Frontier Science Program","keywords":"Link (geometry); Computational biology; Chemistry; Evolutionary biology; Biology; Mathematics; Combinatorics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000113467,0.0003802136,0.0006116775,0.0002133207,0.00008671762,0.00002571059,0.0001799576,0.0005623946,0.00001444897],"category_scores_gemma":[0.0000940691,0.0002960061,0.0001606881,0.0001593579,0.0001280299,0.000008220565,0.0002207869,0.0003549915,0.000004400656],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005218681,"about_ca_system_score_gemma":0.0003223991,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005531189,"about_ca_topic_score_gemma":0.00000775504,"domain_scores_codex":[0.9984407,0.0001568747,0.0005440651,0.0004988536,0.0000815626,0.0002779312],"domain_scores_gemma":[0.9993563,0.00004187264,0.0002544282,0.0002098197,0.00008051857,0.00005707109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005111491,0.000007088413,0.0002709793,0.008922637,0.0000797856,1.512003e-7,0.000008145224,0.00001206022,0.0001004838,0.01188913,0.0006740783,0.9779844],"study_design_scores_gemma":[0.0004581965,0.0001044527,0.0003769806,0.002624501,0.00003681851,0.00004500885,0.000004955437,0.0001062859,0.00001824527,0.004990853,0.9908029,0.000430807],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006412299,0.9947537,0.000755622,0.00003489119,0.002598045,0.0007703437,0.0003851846,0.00001569752,0.00004532666],"genre_scores_gemma":[0.001070271,0.9814407,0.000114022,0.000009141326,0.0009144869,0.0001829574,0.01621903,0.00001321761,0.00003620847],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9901288,"threshold_uncertainty_score":0.9999492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02157193140033452,"score_gpt":0.3265909291831115,"score_spread":0.305018997782777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}