{"id":"W4413301417","doi":"10.1101/2025.08.13.670211","title":"Exploring Cerebellar–Hippocampal Dynamics in Temporal Lobe Epilepsy: A Multivariable Synthetic Modeling Study of Purkinje Cell Degeneration and Stimulation Timing","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Cumming School of Medicine, University of Calgary","keywords":"Neuroscience; Temporal lobe; Hippocampal formation; Epilepsy; Purkinje cell; Stimulation; Cerebellum; Degeneration (medical); Medicine; Psychology; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005448753,0.0005203994,0.0006115664,0.0005626278,0.0003657999,0.000801189,0.001108959,0.0007028242,0.003194048],"category_scores_gemma":[0.01214506,0.0003043427,0.001648567,0.0005589155,0.0005798488,0.0003654151,0.0009672578,0.0009259008,0.0001614654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006684904,"about_ca_system_score_gemma":0.001143024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01871316,"about_ca_topic_score_gemma":0.009465466,"domain_scores_codex":[0.9985668,0.001049719,0.00004438031,0.0001996393,0.00005070035,0.00008880808],"domain_scores_gemma":[0.9887311,0.009801459,0.0005987082,0.0004389398,0.0002832571,0.0001464877],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.001139372,0.0005217653,0.2448052,0.0002377511,0.002004043,0.0007919574,0.0008771961,0.7079418,0.001487774,0.01724129,0.00132564,0.02162623],"study_design_scores_gemma":[0.0001095541,0.0004767769,0.02114409,0.00002889233,0.0004912926,0.000118263,0.0002975697,0.9698235,0.0003920041,0.00576702,0.001321779,0.00002927145],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624293,0.0002168613,0.03518863,0.0003457335,0.00002240158,0.00009719405,0.001115397,0.00006008047,0.0005243786],"genre_scores_gemma":[0.992456,0.00007893426,0.006356219,0.00003293401,0.000008457961,0.0001242663,0.0005423187,0.000007823791,0.0003931263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01871316,"threshold_uncertainty_score":0.03720844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1027437670452218,"score_gpt":0.2991106984599378,"score_spread":0.196366931414716,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}