{"id":"W4413305591","doi":"10.1136/bcr-2025-265370","title":"Discordance between biochemical and histological severity in persistent immune checkpoint inhibitor induced liver injury","year":2025,"lang":"en","type":"article","venue":"BMJ Case Reports","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre; Toronto General Hospital","funders":"","keywords":"Immunosuppression; Medicine; Liver injury; Nivolumab; Ipilimumab; Liver biopsy; Prednisone; Elevated liver enzymes; Histopathology; Biopsy; Hepatitis; Internal medicine; Immune system; Gastroenterology; Pathology; Immunology; Immunotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004845796,0.0001653482,0.0004203886,0.0001152749,0.00005814584,0.00001414595,0.00002391073,0.0001769181,0.00004171665],"category_scores_gemma":[0.0001850332,0.0001367002,0.0001775943,0.0002442471,0.0001557986,0.00004799769,0.00007615979,0.0002714604,0.000001155731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003081851,"about_ca_system_score_gemma":0.000194831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008122982,"about_ca_topic_score_gemma":0.00003096272,"domain_scores_codex":[0.998512,0.00004546571,0.0006678036,0.0004038917,0.0001562972,0.0002145024],"domain_scores_gemma":[0.9993088,0.00004192424,0.0001666734,0.000352404,0.00004243437,0.00008779934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00303257,0.0005100608,0.1508461,0.0005826115,0.0003566933,0.3052037,0.0004974777,8.724985e-8,0.4762644,0.000008359303,0.001504194,0.06119365],"study_design_scores_gemma":[0.002590878,0.0006839306,0.6449434,0.001198979,0.0002907061,0.1942217,0.0004997156,0.00003516389,0.1507346,0.00006299186,0.004232026,0.0005059734],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943296,0.003180072,0.000008278104,0.001146662,0.0002314311,0.0006300761,0.000004009143,0.00003539862,0.0004345093],"genre_scores_gemma":[0.9990841,0.0001026143,0.0001645709,0.0001915363,0.00009228997,0.00005225691,0.00001539266,0.000008755305,0.0002884422],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4940973,"threshold_uncertainty_score":0.5574474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02869975490370945,"score_gpt":0.3139512443864932,"score_spread":0.2852514894827837,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}