{"id":"W4413306010","doi":"10.3390/proceedings2025124018","title":"Human Antibodies to M-Protein Epitope-Based Vaccines Demonstrate Increased Immunogenicity and Streptococcus pyogenes (StrepA) Bactericidal Activity","year":2025,"lang":"en","type":"article","venue":"","topic":"Streptococcal Infections and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Immunogenicity; Streptococcus pyogenes; Epitope; Microbiology; Antibody; Virology; Biology; Immunology; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002794349,0.0002987182,0.0002021396,0.0001564268,0.00008001663,0.0002104058,0.0001408204,0.0003453972,0.002696306],"category_scores_gemma":[0.0002991271,0.00007988877,0.0001626686,0.0001087188,0.0001316199,0.0001312063,0.0001364035,0.0005217952,0.0006346736],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001554751,"about_ca_system_score_gemma":0.0001068595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003079679,"about_ca_topic_score_gemma":0.0003023147,"domain_scores_codex":[0.9999123,0.0000189126,0.000005365065,0.00001333886,0.00002223598,0.00002781071],"domain_scores_gemma":[0.9998921,0.00003215068,0.00002161661,0.00001247627,0.00002561062,0.00001603493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000501628,0.0002794367,0.001162223,0.0001351694,0.00002461576,0.00009957657,0.00002857603,0.000218114,0.9680156,0.0003015248,0.0007945992,0.02843896],"study_design_scores_gemma":[0.0001392994,0.005148526,0.01690765,0.00003061978,0.00004304619,0.001009495,0.00004057022,0.001009463,0.9646614,0.0001828625,0.01081994,0.000007171731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832855,0.005253574,0.004851488,0.0004154524,0.0001520919,0.00007460236,0.0002875367,0.0001736258,0.005506168],"genre_scores_gemma":[0.9936517,0.001356605,0.001851458,0.0002435976,0.00004792902,0.00001901611,0.0004105475,0.00001311644,0.002405871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002696306,"threshold_uncertainty_score":0.00902003,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01480328332729581,"score_gpt":0.3125720826543622,"score_spread":0.2977687993270664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}