{"id":"W4413307651","doi":"10.3389/fonc.2025.1609735","title":"Combined treatment with CDK4/6, CDK2, and CXCR1/2 inhibitors effectively halts the growth of BRAF wild-type melanoma tumors","year":2025,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"National Cancer Institute; U.S. Department of Veterans Affairs","keywords":"Cancer research; Melanoma; Medicine; Oncology; Cyclin-dependent kinase 2; Internal medicine; Cell cycle; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001655762,0.000609307,0.0004678152,0.0003714154,0.0001333952,0.0002932191,0.0003013771,0.0002273523,0.002431958],"category_scores_gemma":[0.00006204044,0.0001777829,0.0003307825,0.0001760787,0.0001717336,0.000247781,0.0001833703,0.0008245336,0.0005065309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003797113,"about_ca_system_score_gemma":0.000485935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000846137,"about_ca_topic_score_gemma":0.002071314,"domain_scores_codex":[0.9998345,0.00002261332,0.00001126154,0.00003298135,0.0000465841,0.00005201805],"domain_scores_gemma":[0.99993,0.000007224055,0.00001405154,0.000008844245,0.000006331472,0.00003357174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001193419,0.0009191377,0.0008199321,0.0001249418,0.00006125966,0.00006157008,0.00001326941,0.0003782391,0.9812766,0.0001148875,0.0006534632,0.01438329],"study_design_scores_gemma":[0.0002643846,0.007876017,0.003872582,0.00000887667,0.00007368073,0.0003124488,0.00001585604,0.001762176,0.9810023,0.00003492254,0.004768016,0.000008620794],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919311,0.003283277,0.001214474,0.0001239451,0.00007739649,0.00007294674,0.0003048752,0.0001874317,0.002804458],"genre_scores_gemma":[0.9921257,0.001325293,0.002665435,0.0000552729,0.00002684441,0.0000645384,0.0007405846,0.00002719845,0.002968911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002431958,"threshold_uncertainty_score":0.008135736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006008888807331593,"score_gpt":0.2659323550839981,"score_spread":0.2599234662766665,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}