{"id":"W4413308588","doi":"10.3390/cells14161284","title":"Decoding ADGRE5: How Proteolytic Cleavage and Mechanical Forces Unleash Cellular Signals","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Receptor; Chemistry; Signal transduction; Cell biology; Proteolysis; G protein-coupled receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002433487,0.0001618985,0.0001741986,0.00004591934,0.0001153291,0.00008259903,0.0001605453,0.0001853878,0.00005457856],"category_scores_gemma":[0.00004089511,0.0001494538,0.00008292171,0.00007512401,0.00004007885,0.000005004719,0.0001449022,0.00009473201,0.000008145998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009228339,"about_ca_system_score_gemma":0.00004003869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003695932,"about_ca_topic_score_gemma":0.000002786347,"domain_scores_codex":[0.9990553,0.00005410162,0.0001520962,0.0003837641,0.00009585339,0.0002588537],"domain_scores_gemma":[0.9995712,0.00002041268,0.00005794333,0.0002250508,0.00003957404,0.00008580132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002214423,0.00002502698,0.00002136,0.00004857939,0.00003314299,0.000003593653,0.00001637998,0.000008504097,0.9948772,0.0007233493,0.001591558,0.00262913],"study_design_scores_gemma":[0.0004439196,0.0001273809,0.000004354335,0.00004765498,0.00002644959,0.000001767136,0.0001087947,0.0006035587,0.9853681,0.000885893,0.01221417,0.0001679331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9139486,0.001968505,0.08114514,0.0002530942,0.0003757515,0.0004730264,0.000007549427,0.00002770965,0.001800602],"genre_scores_gemma":[0.9930997,0.0001853518,0.002173284,0.0002710608,0.0001315213,0.00002262862,0.0000144577,0.00001863595,0.004083334],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0791511,"threshold_uncertainty_score":0.609455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007149689824899871,"score_gpt":0.2219512801135494,"score_spread":0.2148015902886495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}