{"id":"W4413308588","doi":"10.3390/cells14161284","title":"Decoding ADGRE5: How Proteolytic Cleavage and Mechanical Forces Unleash Cellular Signals","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute for Research in Immunology and Cancer; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Mitacs","keywords":"Receptor; Chemistry; Signal transduction; Cell biology; Proteolysis; G protein-coupled receptor; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002430921,0.0003778666,0.0002436978,0.000138806,0.000147367,0.0005228474,0.0002733526,0.0004165562,0.002292839],"category_scores_gemma":[0.0001812993,0.0001613663,0.0002344381,0.0001210001,0.0002363825,0.0003742704,0.0003177919,0.0007992755,0.0008907274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004471178,"about_ca_system_score_gemma":0.000162712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003630968,"about_ca_topic_score_gemma":0.0005823683,"domain_scores_codex":[0.9998128,0.00002694017,0.00001787765,0.00004440028,0.00005619201,0.00004187477],"domain_scores_gemma":[0.9999181,0.00001545356,0.00002258458,0.00001168752,0.00001131638,0.00002086584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009516519,0.00001258679,0.0001626333,0.00005260947,0.000005056675,0.00007714867,0.00001391309,0.0001567621,0.996299,0.000376582,0.0001121224,0.002636339],"study_design_scores_gemma":[0.00001251211,0.0001194456,0.000670797,0.000005958611,0.000007042594,0.000216382,0.00002719621,0.001315715,0.9923741,0.00008857962,0.005156284,0.000005799242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777926,0.002876032,0.01345924,0.0005102138,0.0001306369,0.00006474892,0.0006953747,0.0002292361,0.004241931],"genre_scores_gemma":[0.9820634,0.001412296,0.009931706,0.0002133651,0.00001655674,0.00003714719,0.001012725,0.00005895918,0.005253932],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002292839,"threshold_uncertainty_score":0.007670343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007149689824899871,"score_gpt":0.2219512801135494,"score_spread":0.2148015902886495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}