{"id":"W4413311393","doi":"10.3390/cancers17162698","title":"Intracellular Targeted Nanocapsules Containing Nanobiotherapeutic Suppress Lung, Liver, Breast and Cervix Cancer Cell Lines by Prodrug Activation or Removal of Intracellular Tyrosine","year":2025,"lang":"en","type":"article","venue":"Cancers","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"McGill University","keywords":"Intracellular; Prodrug; Quercetin; Tyrosinase; HeLa; Cytotoxicity; Tyrosine; Pharmacology; Chemistry; Extracellular; Biochemistry; Cancer research; Biology; Cell; Enzyme; Antioxidant","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008205255,0.0003031369,0.0001657594,0.000114636,0.00006558117,0.0001396367,0.0001322277,0.0002841747,0.0007655603],"category_scores_gemma":[0.00006020102,0.00009524864,0.0001889163,0.00006636664,0.0001610794,0.0001383763,0.0001180137,0.0002096111,0.000189849],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002379613,"about_ca_system_score_gemma":0.0001327948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007156156,"about_ca_topic_score_gemma":0.001148559,"domain_scores_codex":[0.9999335,0.000006006566,0.000005472568,0.00001974051,0.00002150097,0.00001382706],"domain_scores_gemma":[0.9999616,0.000009012433,0.00001286403,0.000004506326,0.000006772788,0.000005245267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001740467,0.000009016026,0.00003263425,0.00001968408,0.000001363753,0.000009226806,0.000004069422,0.00006046193,0.9994038,0.00002222924,0.000008248902,0.0004119532],"study_design_scores_gemma":[0.000004623167,0.0001341641,0.0002754302,0.000001929904,0.000004828974,0.0000266156,0.000002957467,0.0003363517,0.9988952,0.000004463781,0.0003122412,0.000001182401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918898,0.001073526,0.005538368,0.00004552957,0.00001622817,0.00004932992,0.0001033099,0.0000554416,0.001228541],"genre_scores_gemma":[0.9920283,0.0006648919,0.00523195,0.00003656225,0.000005501576,0.00005621098,0.0001453577,0.00001452598,0.001816623],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007655603,"threshold_uncertainty_score":0.002561033,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006974674144084891,"score_gpt":0.2500039907242202,"score_spread":0.2430293165801353,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}