{"id":"W4413311458","doi":"10.15420/cfr.2025.09","title":"The Emerging Role of Aldosterone Synthase Inhibitors in Overcoming Renin–Angiotensin–Aldosterone System Therapy Limitations: A Narrative Review","year":2025,"lang":"en","type":"review","venue":"Cardiac failure review","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital; St. Michael's Hospital; University of Toronto","funders":"Amarin Corporation; Novo Nordisk; Sanofi; HLS Therapeutics; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Narrative review; Aldosterone synthase; Renin–angiotensin system; Aldosterone; Medicine; Narrative; Internal medicine; Endocrinology; Pharmacology; Intensive care medicine; Blood pressure; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002231366,0.0008202907,0.007033911,0.0003665597,0.0002043871,0.00003397821,0.000294858,0.0003723969,0.0000136677],"category_scores_gemma":[0.001623161,0.0005071696,0.002384089,0.001790367,0.000130712,0.0001298193,0.0001460082,0.0007650776,0.00003776123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004352527,"about_ca_system_score_gemma":0.0009187621,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001983607,"about_ca_topic_score_gemma":0.00001210318,"domain_scores_codex":[0.9938303,0.001578846,0.002648357,0.0007238623,0.0007565088,0.0004621439],"domain_scores_gemma":[0.9952234,0.00135282,0.001285886,0.001300086,0.0006483644,0.0001894284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001294676,0.00003133062,0.000002000605,0.1667244,0.0004517973,0.00002471943,0.00008985867,1.011522e-7,0.000007846183,0.0001215473,0.0216838,0.8108497],"study_design_scores_gemma":[0.0001857993,0.00004424491,0.000004753453,0.4621376,0.00203071,0.0000687528,0.0001221991,0.000001878776,0.000001886251,0.000001240608,0.5351993,0.0002017274],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002105227,0.9864872,0.0000043096,0.005125402,0.0003420681,0.007310392,0.00003889391,0.00006315098,0.0006264727],"genre_scores_gemma":[0.00002288669,0.9975406,0.0002829301,0.0005968284,0.0001821287,0.0007622944,0.0002611126,0.00008414534,0.0002670779],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.810648,"threshold_uncertainty_score":0.999738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03688842619975679,"score_gpt":0.3248523928875585,"score_spread":0.2879639666878017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}