{"id":"W4413311458","doi":"10.15420/cfr.2025.09","title":"The Emerging Role of Aldosterone Synthase Inhibitors in Overcoming Renin–Angiotensin–Aldosterone System Therapy Limitations: A Narrative Review","year":2025,"lang":"en","type":"review","venue":"Cardiac failure review","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Toronto General Hospital; St. Michael's Hospital; University of Toronto","funders":"Amarin Corporation; Novo Nordisk; Sanofi; HLS Therapeutics; Amgen; Pfizer; AstraZeneca; Eli Lilly and Company","keywords":"Narrative review; Aldosterone synthase; Renin–angiotensin system; Aldosterone; Medicine; Narrative; Internal medicine; Endocrinology; Pharmacology; Intensive care medicine; Blood pressure; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001074937,0.0008151205,0.002263873,0.003703889,0.0003205952,0.001493897,0.0009712707,0.001167702,0.005992684],"category_scores_gemma":[0.002904018,0.0002795404,0.001560096,0.003920147,0.0003399744,0.001505462,0.0007359192,0.001114537,0.000830652],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007541774,"about_ca_system_score_gemma":0.002879831,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001481047,"about_ca_topic_score_gemma":0.003422963,"domain_scores_codex":[0.9995335,0.0001127123,0.0001406244,0.00005968566,0.0001226087,0.00003089396],"domain_scores_gemma":[0.9982633,0.001252404,0.0002335673,0.00002145014,0.0001919606,0.00003732724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000153161,0.00004651764,0.0002165349,0.3992907,0.0006737188,0.0003366423,0.0001942841,0.0002311711,0.0007252377,0.002794354,0.02499461,0.5703431],"study_design_scores_gemma":[0.00008947928,0.0002102067,0.00174153,0.2281507,0.004473655,0.002448141,0.0002834126,0.000155029,0.0003245567,0.002377962,0.7596993,0.00004594048],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005377945,0.9994382,0.00003243478,0.0001434782,0.00008460751,0.000006513991,0.00001829781,0.000002085466,0.0002205159],"genre_scores_gemma":[0.0004316978,0.9991393,0.00008711247,0.000158872,0.00007596926,0.000008786837,0.00001839854,6.494215e-7,0.00007916514],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.005992684,"threshold_uncertainty_score":0.02004749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03688842619975679,"score_gpt":0.3248523928875585,"score_spread":0.2879639666878017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}