{"id":"W4413315181","doi":"10.1172/jci190989","title":"A distinct mechanism of epigenetic reprogramming silences PAX2 and initiates endometrial carcinogenesis","year":2025,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"L'Alliance Boviteq","funders":"National Cancer Institute; Japan Society for the Promotion of Science; National Institutes of Health; Cancer Prevention and Research Institute of Texas; Mary Kay Foundation","keywords":"Reprogramming; Epigenetics; Carcinogenesis; Mechanism (biology); Epigenesis; Biology; Cell biology; DNA methylation; Cancer research; Endometrial cancer; Genetics; Cancer; Gene; Gene expression; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001521199,0.0001967863,0.0002044463,0.0002390629,0.0001918681,0.0003799115,0.0002069881,0.0002540745,0.0009830812],"category_scores_gemma":[0.0001927934,0.0001641742,0.0002637896,0.0001751567,0.0003019627,0.0002922743,0.0004611768,0.0003741302,0.0002453947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002031004,"about_ca_system_score_gemma":0.0002218619,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003307765,"about_ca_topic_score_gemma":0.0006427517,"domain_scores_codex":[0.9998674,0.00001407818,0.000007212974,0.00003856931,0.00004597988,0.00002660154],"domain_scores_gemma":[0.9999324,0.000009713378,0.0000194034,0.00001627013,0.000009544882,0.00001261527],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000774936,0.000006282206,0.001767475,0.00004148839,0.0000105758,0.0001588141,0.00003962151,0.0001336673,0.989349,0.001364022,0.00005265869,0.006998828],"study_design_scores_gemma":[0.00001843524,0.0001960582,0.02261955,0.0000165917,0.00003142964,0.001652764,0.0001218495,0.002200095,0.9591835,0.0009570907,0.01298771,0.00001493068],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9572259,0.006505619,0.02857518,0.0002973127,0.00007673969,0.00005237871,0.000513401,0.0002716332,0.006481801],"genre_scores_gemma":[0.9934476,0.001378232,0.002747346,0.00007552892,0.00001460382,0.00002406889,0.0002968574,0.00001830246,0.001997577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009830812,"threshold_uncertainty_score":0.003288746,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03955910198113187,"score_gpt":0.349364826129087,"score_spread":0.3098057241479552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}