{"id":"W4413318187","doi":"10.1021/acsinfecdis.5c00394","title":"Common Biological Properties of <i>Mycobacterium tuberculosis</i> MmpL3 Inhibitors","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"NHLBI Division of Intramural Research; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Foundation for the National Institutes of Health","keywords":"Biochemistry; Mycobacterium tuberculosis; Biology; Bacteria; Cell wall; Bacilli; Enzyme; Chemistry; Tuberculosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001850308,0.0001967807,0.0006083226,0.0002265411,0.0001099891,0.00001491294,0.0001118825,0.0001682416,0.0000671916],"category_scores_gemma":[0.001445129,0.0001355872,0.0002288936,0.0003875965,0.0004117595,0.00007683037,0.0001625443,0.0002405529,0.00003640234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009329855,"about_ca_system_score_gemma":0.0001609837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003677638,"about_ca_topic_score_gemma":0.00003865839,"domain_scores_codex":[0.9984341,0.0002346087,0.0004463853,0.0003162506,0.0001696233,0.0003990002],"domain_scores_gemma":[0.9989287,0.0002237892,0.00007636943,0.000387741,0.0001765631,0.0002068069],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003251203,0.0006965274,0.9291586,0.0003732143,0.0002760306,0.00001371082,0.00002471532,0.000005086436,0.052158,0.0007494909,0.01288317,0.003336338],"study_design_scores_gemma":[0.001878201,0.001143882,0.9133685,0.0005900024,0.0003710577,0.0000664129,0.0001128426,0.00003473623,0.06645314,0.00161278,0.01408385,0.0002846131],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875593,0.003635295,0.000008632732,0.002264133,0.0002715594,0.0004409242,0.00003434263,0.0001860574,0.005599791],"genre_scores_gemma":[0.995919,0.001222667,0.000008687275,0.002380341,0.000154895,0.0001028837,0.00004943968,0.00001316118,0.0001488887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01579011,"threshold_uncertainty_score":0.5529085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02262785622287052,"score_gpt":0.3018747006825777,"score_spread":0.2792468444597072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}