{"id":"W4413318187","doi":"10.1021/acsinfecdis.5c00394","title":"Common Biological Properties of <i>Mycobacterium tuberculosis</i> MmpL3 Inhibitors","year":2025,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Tuberculosis Research and Epidemiology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"NHLBI Division of Intramural Research; Bill and Melinda Gates Foundation; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; National Institute of Allergy and Infectious Diseases; National Institutes of Health; Foundation for the National Institutes of Health","keywords":"Biochemistry; Mycobacterium tuberculosis; Biology; Bacteria; Cell wall; Bacilli; Enzyme; Chemistry; Tuberculosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798976,0.0003713426,0.000294698,0.0003120813,0.0001554622,0.0002315886,0.0002127642,0.0003287015,0.001879989],"category_scores_gemma":[0.0002167607,0.0001165397,0.0002580822,0.0002573374,0.0001570523,0.000179086,0.000139176,0.0003665871,0.0003778543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002134699,"about_ca_system_score_gemma":0.0001285124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003600545,"about_ca_topic_score_gemma":0.0004644998,"domain_scores_codex":[0.9997905,0.00004115727,0.00001929937,0.00003804719,0.0000684922,0.0000424801],"domain_scores_gemma":[0.9998541,0.00003502735,0.00004397061,0.000011957,0.00002965557,0.00002524962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001956942,0.00003815115,0.0002299984,0.00008319376,0.00001176271,0.00006161862,0.00001208439,0.0001554089,0.9951969,0.00006676415,0.0001346348,0.003813788],"study_design_scores_gemma":[0.00002401442,0.00117338,0.003013934,0.000008866325,0.00002513418,0.0003996465,0.00001446456,0.000411502,0.9914415,0.00003959112,0.00344096,0.000007133878],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9700952,0.01286597,0.005289855,0.0003083261,0.00006384746,0.0001444481,0.001786552,0.0002286675,0.009217185],"genre_scores_gemma":[0.9864071,0.003619208,0.004259858,0.0001945312,0.0000322708,0.0000791034,0.001749626,0.00004479041,0.003613655],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001879989,"threshold_uncertainty_score":0.006289184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02262785622287052,"score_gpt":0.3018747006825777,"score_spread":0.2792468444597072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}