{"id":"W4413323486","doi":"10.1016/j.xcrm.2025.102303","title":"TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation","year":2025,"lang":"en","type":"article","venue":"Cell Reports Medicine","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Michael Smith Health Research BC; BC Children's Hospital; Canadian Institutes of Health Research; Bristol-Myers Squibb","keywords":"Function (biology); Cell biology; Immunology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002923588,0.0001997556,0.0003341819,0.0002030268,0.0002929147,0.00001732935,0.00003507681,0.000249831,0.0003246016],"category_scores_gemma":[0.00008485869,0.0001565576,0.00003695008,0.0001373054,0.0002395277,0.0001248947,0.00007568955,0.0002301243,0.000009214028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002705427,"about_ca_system_score_gemma":0.00002679544,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008526933,"about_ca_topic_score_gemma":0.00003791759,"domain_scores_codex":[0.9986312,0.000132179,0.0005153398,0.0004368961,0.00004930728,0.0002351124],"domain_scores_gemma":[0.9991952,0.0001130359,0.0003776145,0.0002186392,0.00007463159,0.00002086135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006166959,0.0000955549,0.009595549,0.0001124125,0.00007507122,0.000006991909,0.0004076296,2.933511e-7,0.9747384,0.0001848764,0.00179335,0.01292824],"study_design_scores_gemma":[0.002236403,0.0003932385,0.08884671,0.0004003107,0.0004626382,0.0001268667,0.0008963903,0.00002252336,0.890053,0.003010832,0.01330718,0.0002439463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789578,0.01179084,0.002008877,0.0004821331,0.001979622,0.0002994116,0.000001375115,0.0000852762,0.004394691],"genre_scores_gemma":[0.9854544,0.0009813135,0.00001071953,0.0001160084,0.00007673984,0.00002808042,0.0003543517,0.00001029517,0.01296807],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08468539,"threshold_uncertainty_score":0.6384234,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00789673738561187,"score_gpt":0.2146430619601547,"score_spread":0.2067463245745428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}