{"id":"W4413324672","doi":"10.1016/j.cej.2025.167391","title":"Linking gut, heart and metabolic health through cholesterol conversion by Akkermansia muciniphila","year":2025,"lang":"en","type":"article","venue":"Chemical Engineering Journal","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Interior Health; Okanagan University College; Kelowna General Hospital; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"Research and Development; Canadian Glycomics Network","keywords":"Akkermansia muciniphila; Cholesterol; Microbiology; Chemistry; Medicine; Internal medicine; Biology; Biochemistry; Gut flora","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435643,0.0003126704,0.0001818185,0.0001311921,0.0001686655,0.0003187076,0.0001522538,0.0003477267,0.0006485825],"category_scores_gemma":[0.000154611,0.0000956661,0.0002417778,0.0001065252,0.0002111044,0.0002109062,0.0005164347,0.0004752027,0.0001440035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002013788,"about_ca_system_score_gemma":0.0001734996,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117644,"about_ca_topic_score_gemma":0.0009064371,"domain_scores_codex":[0.999908,0.00001466871,0.000009275594,0.00001865541,0.00002370531,0.00002570183],"domain_scores_gemma":[0.9999236,0.00001356632,0.00002759065,0.000009434326,0.000009160174,0.00001667438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006236189,0.00001307185,0.000278946,0.00001663869,0.000002927257,0.0000429191,0.00001288141,0.00003635279,0.9987657,0.00005012333,0.00001154443,0.0007065251],"study_design_scores_gemma":[0.00002055128,0.0005002268,0.01809373,0.00001525358,0.00003355756,0.0003367565,0.0001879923,0.001025781,0.9766113,0.0001437253,0.003017978,0.00001316872],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974363,0.0004640298,0.0009584911,0.0002776096,0.00003259176,0.00001026029,0.0001144768,0.00004225521,0.0006639689],"genre_scores_gemma":[0.9972124,0.0002804231,0.001210156,0.00006153197,0.000007331502,0.000009147107,0.0001082137,0.000006224634,0.001104618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00117644,"threshold_uncertainty_score":0.002339125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004981336725846336,"score_gpt":0.2448471441038485,"score_spread":0.2398658073780021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}