{"id":"W4413326227","doi":"10.3390/cells14161286","title":"Mutation of MeCP2 at T158M Leads to Distinct Molecular and Phenotypic Abnormalities in Male and Female Mice","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; Natural Sciences and Engineering Research Council of Canada; Ontario Rett Syndrome Association","keywords":"MECP2; Rett syndrome; Biology; Epigenetics; Phenotype; Genetics; Mutation; Mutant; Transgene; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000226076,0.0009833473,0.0004062672,0.001767009,0.0003025967,0.0004626486,0.0006020956,0.001013249,0.004251766],"category_scores_gemma":[0.0002430187,0.0004803201,0.0005853608,0.0003563084,0.0006270655,0.0002949864,0.000635986,0.001288465,0.001220003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000344328,"about_ca_system_score_gemma":0.0002515485,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008155489,"about_ca_topic_score_gemma":0.001050467,"domain_scores_codex":[0.99936,0.00006841793,0.00008870318,0.0002084884,0.0001723692,0.0001019918],"domain_scores_gemma":[0.9993657,0.00007310427,0.0002938523,0.00004036604,0.00002627926,0.0002005606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001831203,0.00007906324,0.0004931291,0.00002893863,0.00001417165,0.0005393583,0.0000490149,0.0000466309,0.9969476,0.0001984571,0.0000794594,0.001341147],"study_design_scores_gemma":[0.0001251915,0.0009574395,0.03865709,0.00005899848,0.00008717198,0.007747007,0.0002138538,0.0009094295,0.9464453,0.0003039858,0.004453232,0.00004121265],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894958,0.001202156,0.002943955,0.0002450647,0.00007068855,0.00004890316,0.002715356,0.0003301771,0.002947843],"genre_scores_gemma":[0.9773014,0.001460051,0.003398448,0.0002316282,0.00004141241,0.0001394443,0.00230009,0.0003286722,0.01479893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004251766,"threshold_uncertainty_score":0.01422364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004982795940625867,"score_gpt":0.2170989475390793,"score_spread":0.2121161515984534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}