{"id":"W4413326227","doi":"10.3390/cells14161286","title":"Mutation of MeCP2 at T158M Leads to Distinct Molecular and Phenotypic Abnormalities in Male and Female Mice","year":2025,"lang":"en","type":"article","venue":"Cells","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Children's Hospital Research Institute of Manitoba; Natural Sciences and Engineering Research Council of Canada; Ontario Rett Syndrome Association","keywords":"MECP2; Rett syndrome; Biology; Epigenetics; Phenotype; Genetics; Mutation; Mutant; Transgene; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000470094,0.0000754911,0.00008127854,0.00004138401,0.00002282069,0.000007346881,0.00004649013,0.00004297461,0.000007953153],"category_scores_gemma":[0.00001218055,0.00008122479,0.00001379707,0.00005909066,0.00004506443,0.000001321623,0.0001211882,0.00002341247,0.000001707424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005644272,"about_ca_system_score_gemma":0.00001771817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002348499,"about_ca_topic_score_gemma":0.0001013234,"domain_scores_codex":[0.9995402,0.00001938347,0.0001159699,0.0001842892,0.00003914964,0.0001010165],"domain_scores_gemma":[0.9998402,0.000007027803,0.00002192111,0.00008443752,0.00001731766,0.00002912044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003425593,0.0000165721,0.01226975,0.00006943685,0.00000643365,0.000002546865,0.0001309355,0.0000571368,0.98658,0.00005284408,0.0001235698,0.0006564758],"study_design_scores_gemma":[0.0002926143,0.00006526485,0.07321784,0.00001594528,0.000006699313,0.000002727325,0.0001207926,0.00001477875,0.9249225,0.00006790459,0.001188407,0.00008450593],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996505,0.001027582,0.0001793853,0.00006640075,0.00004064328,0.0001220927,0.000009425699,0.000001602033,0.002047864],"genre_scores_gemma":[0.9975662,0.0001133815,0.0004026865,0.0002102803,0.000002018185,0.000008034489,0.00002093253,0.000006044067,0.001670448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06165752,"threshold_uncertainty_score":0.3312251,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004982795940625867,"score_gpt":0.2170989475390793,"score_spread":0.2121161515984534,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}