{"id":"W4413326697","doi":"10.1101/2025.08.15.25331829","title":"Cognitive Reserve Disrupts Cognitive Decline from White Matter Hyperintensities","year":2025,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Advanced Neuroimaging Techniques and Applications","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas College; York University; Carleton University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Japan Atomic Energy Agency; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; Natural Sciences and Engineering Research Council of Canada; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; Alzheimer's Association","keywords":"Hyperintensity; Cognition; Cognitive reserve; Cognitive decline; Effects of sleep deprivation on cognitive performance; Disconnection; Psychology; Lesion; Neuroscience; White matter; Magnetic resonance imaging; Cognitive impairment; Medicine; Dementia; Internal medicine; Disease; Psychiatry; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008783001,0.0004000773,0.0002642817,0.0007607935,0.0002322196,0.0007091945,0.0002737694,0.0002805548,0.001332403],"category_scores_gemma":[0.003709123,0.0001622111,0.0004459709,0.0005863947,0.0005461377,0.000592374,0.0008982611,0.000542926,0.0001431301],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002649576,"about_ca_system_score_gemma":0.000431045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006247141,"about_ca_topic_score_gemma":0.01213821,"domain_scores_codex":[0.9998252,0.00005440809,0.00001470209,0.00006231912,0.00002432445,0.00001920614],"domain_scores_gemma":[0.9992145,0.0003380484,0.0002409702,0.000104664,0.00004210668,0.00005965944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002313719,0.0003412305,0.7485076,0.0009676097,0.00223969,0.001148566,0.003176003,0.04126815,0.05509824,0.005285895,0.003993077,0.1356602],"study_design_scores_gemma":[0.00003564403,0.0001962122,0.9481023,0.0000682527,0.0002925218,0.0006893582,0.0004033328,0.03242736,0.005003536,0.01124966,0.00149459,0.00003715031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903702,0.0003046609,0.007438437,0.0001612216,0.000007943474,0.00001603003,0.000925393,0.0001309068,0.0006452049],"genre_scores_gemma":[0.9929327,0.0001829891,0.005431205,0.00004220667,0.00001124045,0.0000267062,0.001043367,0.00002777485,0.0003018077],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006247141,"threshold_uncertainty_score":0.01242155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0849119792704019,"score_gpt":0.3867309130093403,"score_spread":0.3018189337389384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}