{"id":"W4413326965","doi":"10.1016/j.joen.2025.08.004","title":"Endotoxin Levels after Calcium Hydroxide Placement in Root Canals Irrigated with Continuous or Sequential Chelation in Previously Treated Teeth with Symptomatic Apical Periodontitis: A Randomized Controlled Clinical Trial","year":2025,"lang":"en","type":"article","venue":"Journal of Endodontics","topic":"Endodontics and Root Canal Treatments","field":"Dentistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"Faculty of Medicine and Dentistry, University of Alberta","keywords":"Calcium hydroxide; Dentistry; Randomized controlled trial; Periodontitis; Medicine; Chelation therapy; Calcium; Chelation; Clinical trial; Orthodontics; Materials science; Chemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003825813,0.0006224357,0.004521113,0.0008784527,0.00007757375,0.0002515125,0.0003611046,0.0003697621,0.0002077249],"category_scores_gemma":[0.001826502,0.0003598213,0.0007592863,0.000738644,0.0002669242,0.0003008507,0.00006858723,0.0009412171,0.00000680551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007049912,"about_ca_system_score_gemma":0.001257019,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006123009,"about_ca_topic_score_gemma":0.02314547,"domain_scores_codex":[0.99142,0.002073599,0.004221656,0.0005090756,0.001040434,0.000735286],"domain_scores_gemma":[0.994967,0.001928267,0.001926509,0.0004142498,0.0004641116,0.0002998261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7993969,0.001532318,0.1854683,0.00009789797,0.003353368,0.008850412,0.0002925108,0.0004852946,0.0001381411,0.000134509,0.0001066992,0.0001436212],"study_design_scores_gemma":[0.9531373,0.002500962,0.03510108,0.002341835,0.002820771,0.000537064,0.0001903324,0.002119974,0.0006234781,0.00008780739,0.0001101517,0.000429275],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907845,0.0007175051,0.001915774,0.0002611556,0.0007763245,0.004849447,0.00003068348,0.00003150208,0.0006331508],"genre_scores_gemma":[0.9941552,0.00005771012,0.001381326,0.00009614434,0.0002002486,0.0003733466,0.00001563938,0.00006084689,0.003659545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1537404,"threshold_uncertainty_score":0.9998854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03566475977768473,"score_gpt":0.3522370310587283,"score_spread":0.3165722712810435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}