{"id":"W4413332430","doi":"10.1016/j.celrep.2025.116160","title":"Structural basis of peptide recognition and modulation for neuropeptide FF receptors","year":2025,"lang":"en","type":"article","venue":"Cell Reports","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Program of Shanghai Academic Research Leader; China Postdoctoral Science Foundation; National Natural Science Foundation of China; Canadian Anesthesiologists' Society; Shanghai Lingjun Program","keywords":"Receptor; Neuropeptide; Peptide; Modulation (music); Neuropeptide Y receptor; G protein-coupled receptor; Chemistry; Cell biology; Neuroscience; Biology; Biochemistry; Physics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001180865,0.0001543622,0.0001365674,0.00005974652,0.0001681824,0.0001908452,0.000266328,0.0002857859,0.002520597],"category_scores_gemma":[0.0001193599,0.00007812377,0.0001907955,0.00003650676,0.0001764104,0.000209188,0.000130025,0.0004208417,0.0005756928],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002370474,"about_ca_system_score_gemma":0.0001676246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002595074,"about_ca_topic_score_gemma":0.0004054209,"domain_scores_codex":[0.9999486,0.00001085551,0.000002954786,0.00001024225,0.00001383356,0.0000134128],"domain_scores_gemma":[0.9999611,0.000008241202,0.00001000964,0.000003572092,0.000004474634,0.00001251307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001494625,0.00002699965,0.0001560238,0.00003338186,0.000006396402,0.0002183974,0.00002294781,0.0003548886,0.9927509,0.003612411,0.0001361248,0.002532068],"study_design_scores_gemma":[0.000185931,0.001025016,0.01095308,0.00003324962,0.0000355412,0.002443918,0.0001423472,0.01037725,0.9581341,0.003702326,0.01293728,0.00002998873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748165,0.00159414,0.01289974,0.000455191,0.0001022142,0.00004153361,0.0001304514,0.00008425847,0.009875811],"genre_scores_gemma":[0.9950617,0.0004285124,0.002505793,0.0002191008,0.00001812287,0.00001718646,0.0001338884,0.000006449151,0.001609204],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002520597,"threshold_uncertainty_score":0.008432209,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415018534329121,"score_gpt":0.2323534681085367,"score_spread":0.2182032827652454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}