{"id":"W4413335149","doi":"10.1186/s13098-025-01813-6","title":"From background diabetic retinopathy to its proliferative stage. What is the role of gut microbiota in the trajectory of DR? a Mendelian randomization study with mediation analysis","year":2025,"lang":"en","type":"article","venue":"Diabetology & Metabolic Syndrome","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Tongji University; National Natural Science Foundation of China","keywords":"Medicine; Mendelian randomization; Diabetic retinopathy; Diabetes mellitus; Mediation; Gut flora; Randomization; Bioinformatics; Internal medicine; Oncology; Randomized controlled trial; Immunology; Endocrinology; Genetics; Gene; Biology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01256822,0.0009295059,0.0010529,0.0008450215,0.0008236851,0.001126576,0.001523746,0.001410635,0.006760495],"category_scores_gemma":[0.02300399,0.0005334314,0.004225223,0.001162784,0.0009881896,0.0007818379,0.001107197,0.001821589,0.0003821649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008611587,"about_ca_system_score_gemma":0.001445029,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01717648,"about_ca_topic_score_gemma":0.007618199,"domain_scores_codex":[0.9859788,0.007794691,0.0004293815,0.00410552,0.0006849252,0.00100676],"domain_scores_gemma":[0.9887157,0.005814588,0.002047244,0.002613806,0.0004124141,0.0003962507],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02751482,0.0005387489,0.8950211,0.0005550291,0.01227645,0.001446903,0.001353961,0.002460909,0.004392489,0.008339148,0.002456608,0.04364381],"study_design_scores_gemma":[0.002395255,0.005914638,0.899317,0.0004248755,0.01786895,0.00254675,0.00166002,0.04482067,0.002218626,0.0172589,0.00541413,0.0001601479],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9746526,0.002909668,0.01758636,0.001203714,0.0001521214,0.0002540072,0.001553079,0.000173091,0.001515359],"genre_scores_gemma":[0.995451,0.0001655411,0.003153131,0.0001231512,0.0000245656,0.0001560119,0.0002365857,0.00002044812,0.0006694818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01717648,"threshold_uncertainty_score":0.06646788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006907574139631911,"score_gpt":0.2655901247847673,"score_spread":0.2586825506451354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}