{"id":"W4413338809","doi":"10.1038/s44319-025-00555-w","title":"The NuRD component CHD3 promotes BMP signalling during cranial neural crest cell specification","year":2025,"lang":"en","type":"article","venue":"EMBO Reports","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Biotechnology and Biological Sciences Research Council; G. Harold and Leila Y. Mathers Foundation","keywords":"Neural crest; Cranial neural crest; Biology; Cell biology; Wnt signaling pathway; Chromatin; Transcription factor; Genetics; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007752435,0.0002170356,0.0001154078,0.0002483743,0.0001736032,0.0002285291,0.0001978366,0.0002022735,0.0007923367],"category_scores_gemma":[0.0001203881,0.0001409745,0.0001434511,0.00008846491,0.0002892064,0.0001304188,0.0002156941,0.0003308506,0.0002360764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003485858,"about_ca_system_score_gemma":0.0001997455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001398539,"about_ca_topic_score_gemma":0.002453237,"domain_scores_codex":[0.9999112,0.00001204551,0.000006110524,0.00001697822,0.00003216878,0.00002153449],"domain_scores_gemma":[0.9999455,0.00001052065,0.0000116318,0.000005627002,0.000006973128,0.00001970369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006505705,0.000003551305,0.0004760604,0.0000160889,0.000002140368,0.000115056,0.000009018784,0.00003411209,0.9985815,0.0001173542,0.00001477564,0.0005652091],"study_design_scores_gemma":[0.00001015017,0.00003893077,0.01637052,0.000005090603,0.00000921922,0.0004231691,0.00003015797,0.0005229705,0.9813694,0.00008610703,0.001131025,0.000003131818],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994159,0.001279508,0.002058059,0.00007998307,0.00001611899,0.00000897469,0.0002542582,0.00004889868,0.002095192],"genre_scores_gemma":[0.9976645,0.0002987966,0.0009562732,0.00001695146,0.000002665702,0.000007339395,0.0001506534,0.00000843016,0.0008946165],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001398539,"threshold_uncertainty_score":0.002780855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009839349247857574,"score_gpt":0.2403810961947708,"score_spread":0.2305417469469132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}