{"id":"W4413340223","doi":"10.3390/toxins17080413","title":"The Emerging Mycotoxin 2-Amino-14, 16-Dimethyloctadecan-3-ol (AOD) Alters Transcriptional Regulation and Sphingolipid Metabolism and Undergoes N-Acylation by HepG2 Cells","year":2025,"lang":"en","type":"article","venue":"Toxins","topic":"Polysaccharides and Plant Cell Walls","field":"Agricultural and Biological Sciences","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Natural Science Foundation of China; Natural Science Foundation of Jiangxi Province; Georgia Institute of Technology","keywords":"Biology; Sphingolipid; Ceramide synthase; Transcriptome; Gene expression profiling; Biochemistry; Gene; Gene expression; Downregulation and upregulation; Cell biology; Lipid signaling; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002945719,0.0001533507,0.0001511593,0.00001972379,0.0005359252,0.0001660084,0.0001241844,0.00009083508,0.0001085513],"category_scores_gemma":[0.00002006478,0.00006313714,0.00005128032,0.0001904876,0.00008444465,0.0001811217,0.00003494212,0.0001149388,0.00000479586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002163691,"about_ca_system_score_gemma":0.000008687502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005129746,"about_ca_topic_score_gemma":0.000829958,"domain_scores_codex":[0.9989944,0.00008489988,0.0002265521,0.0002772973,0.00016717,0.0002496767],"domain_scores_gemma":[0.9994208,0.0003438157,0.00007837404,0.0000532322,0.00002663401,0.0000772086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002869386,0.00001640936,0.0002122338,0.000007696789,0.00002227106,2.701125e-7,0.0001013074,0.000008229017,0.9553449,0.00296634,0.00286013,0.03843153],"study_design_scores_gemma":[0.0007436402,0.0001258293,0.2086965,0.00008280796,0.0001368143,0.00001130008,0.0009829053,0.003327958,0.2644942,0.0106013,0.5101508,0.0006459534],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990948,0.003143916,0.0001194415,0.003945004,0.000321366,0.0002249272,0.0001003741,0.00004561769,0.001151389],"genre_scores_gemma":[0.994664,0.001397001,0.00006112699,0.0003975917,0.0001327553,0.0000103328,0.00007637549,0.000001328546,0.003259542],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6908507,"threshold_uncertainty_score":0.4121957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00843299865814859,"score_gpt":0.2047371721825066,"score_spread":0.196304173524358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}