{"id":"W4413340223","doi":"10.3390/toxins17080413","title":"The Emerging Mycotoxin 2-Amino-14, 16-Dimethyloctadecan-3-ol (AOD) Alters Transcriptional Regulation and Sphingolipid Metabolism and Undergoes N-Acylation by HepG2 Cells","year":2025,"lang":"en","type":"article","venue":"Toxins","topic":"Polysaccharides and Plant Cell Walls","field":"Agricultural and Biological Sciences","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Natural Science Foundation of China; Natural Science Foundation of Jiangxi Province; Georgia Institute of Technology","keywords":"Biology; Sphingolipid; Ceramide synthase; Transcriptome; Gene expression profiling; Biochemistry; Gene; Gene expression; Downregulation and upregulation; Cell biology; Lipid signaling; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006611346,0.0002102921,0.0001689241,0.0001313473,0.0001048784,0.0001903941,0.00004593075,0.0001275211,0.0007092421],"category_scores_gemma":[0.00006305061,0.00008482609,0.0002323791,0.0001743522,0.00009290571,0.0001020559,0.0001071774,0.0002125351,0.0002158741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001515846,"about_ca_system_score_gemma":0.000151332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001171585,"about_ca_topic_score_gemma":0.00131432,"domain_scores_codex":[0.9999208,0.00001001162,0.000008512197,0.00002010403,0.00002057146,0.00001996979],"domain_scores_gemma":[0.9999636,0.000006365857,0.000009606577,0.000003927325,0.000008096316,0.000008285313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001535881,0.00000998019,0.000822732,0.00002365414,0.000004009637,0.00004727078,0.00001666438,0.00002930618,0.9981645,0.00001432343,0.00002324681,0.0006907126],"study_design_scores_gemma":[0.00001088127,0.0002435596,0.02491658,0.000005723637,0.00002117329,0.000182126,0.000108131,0.0004992008,0.972251,0.00003070003,0.001726091,0.000004702306],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959037,0.001097006,0.001068568,0.0000693392,0.00003006096,0.00001246267,0.0008523396,0.00003671713,0.0009297783],"genre_scores_gemma":[0.9936597,0.0009548656,0.0008365696,0.00009965349,0.000009364271,0.00002797901,0.001148184,0.00001072199,0.003252997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001171585,"threshold_uncertainty_score":0.002372622,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00843299865814859,"score_gpt":0.2047371721825066,"score_spread":0.196304173524358,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}