{"id":"W4413340629","doi":"10.1242/dmm.052253","title":"HTRA1-dependent proteolysis induces age-related retinal degeneration and exacerbates choroidal neovascularization","year":2025,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Cerebrovascular and genetic disorders","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"Genentech","keywords":"Macular degeneration; Choroidal neovascularization; Retinal; Retinal pigment epithelium; Retina; Retinal degeneration; Neovascularization; Biology; PEDF; Pathology; Medicine; Ophthalmology; Cancer research; Angiogenesis; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002559407,0.0002329386,0.0002850733,0.0002034752,0.000173733,0.00008471063,0.00008139794,0.0001372449,0.00009837191],"category_scores_gemma":[0.00005446968,0.0002207536,0.0001808828,0.0002965392,0.00005399479,0.0001346453,0.00006698721,0.0001452615,0.000007529952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004829967,"about_ca_system_score_gemma":0.0001700594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006904585,"about_ca_topic_score_gemma":0.00002411857,"domain_scores_codex":[0.9983794,0.00008861132,0.000307649,0.0005339303,0.0004387831,0.0002516062],"domain_scores_gemma":[0.9991975,0.0000110483,0.00005999094,0.0003737191,0.000126265,0.0002314902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.002122287,0.002533323,0.002982574,0.001906902,0.00362474,0.0003463097,0.003646313,0.05882104,0.4730923,0.2731377,0.0004607441,0.1773257],"study_design_scores_gemma":[0.01057324,0.0004255729,0.02083747,0.0006587338,0.0051484,0.00003357207,0.0008641047,0.3850527,0.1168148,0.4582643,0.0001726383,0.001154552],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.722163,0.002097272,0.2727844,0.0008351763,0.0001219223,0.001095261,0.00001035162,0.0001008007,0.0007918288],"genre_scores_gemma":[0.9949144,0.0002535293,0.002441758,0.0003570056,0.0000298153,0.00017148,0.0003814642,0.00002879295,0.001421792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3562775,"threshold_uncertainty_score":0.9002072,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008597587522765786,"score_gpt":0.2312640162769521,"score_spread":0.2226664287541864,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}