{"id":"W4413343333","doi":"10.1002/acn3.70165","title":"Long‐Term Evaluation of Givinostat in Duchenne Muscular Dystrophy, and Natural History Comparisons","year":2025,"lang":"en","type":"article","venue":"Annals of Clinical and Translational Neurology","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hotel Dieu Hospital","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; Italfarmaco","keywords":"Medicine; Tolerability; Adverse effect; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003395163,0.0004694826,0.0008802526,0.0002715781,0.0003717189,0.0005474313,0.0004786525,0.000590059,0.002505454],"category_scores_gemma":[0.002214266,0.0001754949,0.0009049217,0.0002487914,0.0004511921,0.0005648042,0.0004156929,0.000823609,0.000327633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006910719,"about_ca_system_score_gemma":0.0006304189,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006191484,"about_ca_topic_score_gemma":0.001479138,"domain_scores_codex":[0.9988928,0.000570779,0.0001048095,0.0002055302,0.000146841,0.00007925431],"domain_scores_gemma":[0.9979343,0.0004424566,0.0008814607,0.0001760784,0.000157057,0.0004085541],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.6958321,0.03014737,0.111721,0.001435487,0.003885983,0.0003531046,0.0004292687,0.00115808,0.02265777,0.0001701653,0.000858888,0.1313508],"study_design_scores_gemma":[0.05605092,0.625827,0.3070902,0.0001236421,0.001931201,0.0003844473,0.0002174188,0.0007439802,0.004326249,0.0001846457,0.003071783,0.00004865075],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964164,0.001871042,0.0001869878,0.00005682002,0.00002291169,0.0003751433,0.0003913387,0.00001235416,0.0006669585],"genre_scores_gemma":[0.9972237,0.0005027569,0.0003267831,0.0001225982,0.00004293318,0.0003960805,0.0006668836,0.000003209179,0.0007150916],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003395163,"threshold_uncertainty_score":0.0179556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08243989330508736,"score_gpt":0.3957899941701563,"score_spread":0.3133501008650689,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}